Brown and beige adipocytes are mitochondria-enriched cells capable of dissipating energy
in the form of heat. These thermogenic fat cells were originally considered to function solely …

Transdermal delivery has proven to be one of the most favorable methods among novel
drug delivery systems. Since drugs administered by transdermal delivery systems avoid the …

White fat stores excess energy, whereas brown and beige fat are thermogenic and dissipate
energy as heat. Thermogenic adipose tissues markedly improve glucose and lipid …

The prevalence of obesity has reached pandemic proportions, and now approximately 25%
of adults in Westernized countries have obesity. Recognized as a major health concern …

Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

BACKGROUND Mirabegron is a β3-adrenergic receptor (β3-AR) agonist approved only for
the treatment of overactive bladder. Encouraging preclinical results suggest that β3-AR …

Human brown adipose tissue (BAT) can be activated to increase glucose uptake and energy
expenditure, making it a potential target for treating obesity and metabolic disease. Data on …

Body composition differs between men and women. Men have more lean mass, and women
have more fat mass than men. Men are more likely to accumulate adipose tissue around the …

The demonstration of metabolically active brown adipose tissue (BAT) in humans primarily
using positron emission tomography coupled to computed tomography (PET/CT) with the …

BACKGROUND Beige adipose tissue is associated with improved glucose homeostasis in
mice. Adipose tissue contains β3-adrenergic receptors (β3-ARs), and this study was …