Genetics and epigenetics in asthma

P Ntontsi, A Photiades, E Zervas, G Xanthou… - International journal of …, 2021 - mdpi.com
Asthma is one of the most common respiratory disease that affects both children and adults
worldwide, with diverse phenotypes and underlying pathogenetic mechanisms poorly …

MicroRNAs: roles in regulating neuroinflammation

AD Gaudet, LK Fonken, LR Watkins… - The …, 2018 - journals.sagepub.com
MicroRNAs (miRNAs) are small noncoding RNAs that broadly affect cellular and
physiological function in all multicellular organisms. Here, the role of miRNAs in …

CD38 is robustly induced in human macrophages and monocytes in inflammatory conditions

SA Amici, NA Young, J Narvaez-Miranda… - Frontiers in …, 2018 - frontiersin.org
Macrophages and their monocyte precursors mediate innate immune responses and can
promote a spectrum of phenotypes from pro-inflammatory to pro-resolving. Currently, there …

Detrimental and protective action of microglial extracellular vesicles on myelin lesions: astrocyte involvement in remyelination failure

M Lombardi, R Parolisi, F Scaroni, E Bonfanti… - Acta …, 2019 - Springer
Microglia are highly plastic immune cells which exist in a continuum of activation states. By
shaping the function of oligodendrocyte precursor cells (OPCs), the brain cells which …

MicroRNA-mediated regulation of T helper cell differentiation and plasticity

D Baumjohann, KM Ansel - Nature Reviews Immunology, 2013 - nature.com
Abstract CD4+ T helper (TH) cells regulate appropriate cellular and humoral immune
responses to a wide range of pathogens and are central to the success of vaccines …

MicroRNAs: new players in IBD

R Kalla, NT Ventham, NA Kennedy, JF Quintana… - Gut, 2015 - gut.bmj.com
MicroRNAs (miRNAs) are small non-coding RNAs, 18–23 nucleotides long, which act as
post-transcriptional regulators of gene expression. miRNAs are strongly implicated in the …

A guide to miRNAs in inflammation and innate immune responses

C Nejad, HJ Stunden, MP Gantier - The FEBS journal, 2018 - Wiley Online Library
The discovery of micro RNA s (miRNAs) in the early 1990's has revolutionized our thinking
of post‐transcriptional gene control. miRNAs are involved in the regulation of almost every …

Circulating microRNAs as biomarkers for disease staging in multiple sclerosis

R Gandhi, B Healy, T Gholipour, S Egorova… - Annals of …, 2013 - Wiley Online Library
Objective MicroRNAs (miRNAs) are single‐stranded, small noncoding RNAs that regulate
gene expression. Because they are stable in serum, they are being developed as …

Biomarkers in multiple sclerosis

WJ Housley, D Pitt, DA Hafler - Clinical immunology, 2015 - Elsevier
Substantial effort has been made over the last six decades to identify biomarkers for multiple
sclerosis that can improve disease diagnosis, predict disease progression, and improve …

MicroRNA alteration, application as biomarkers, and therapeutic approaches in neurodegenerative diseases

TPN Nguyen, M Kumar, E Fedele, G Bonanno… - International journal of …, 2022 - mdpi.com
MicroRNAs (miRNAs) are essential post-transcriptional gene regulators involved in various
neuronal and non-neuronal cell functions and play a key role in pathological conditions …