The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune
functions and serves as a pivotal mediator of inflammatory response. In the first part of this …

Research on psoriasis pathogenesis has largely increased knowledge on skin biology in
general. In the past 15 years, breakthroughs in the understanding of the pathogenesis of …

Background Generalized pustular psoriasis (GPP) is a rare, life-threatening, inflammatory
skin disease characterized by widespread eruption of sterile pustules. Interleukin-36 …

Over 20 years ago, it was first proposed that autoinflammation underpins a handful of rare
monogenic disorders characterized by recurrent fever and systemic inflammation. The …

Summary The interleukin‐1 (IL‐1) family of cytokines and receptors is unique in immunology
because the IL‐1 family and Toll‐like receptor (TLR) families share similar functions. More …

Neutrophils are innate immune phagocytes that have a central role in immune defence. Our
understanding of the role of neutrophils in pathogen clearance, immune regulation and …

Psoriatic arthritis (PsA) is part of a group of closely related clinical phenotypes ('psoriatic
disease') that is defined by shared molecular pathogenesis resulting in excessive …

More than any other cytokine family, the 11 members of the IL-1 family are associated with
innate immune responses, which occur in acute inflammation and chronic inflammatory …

The pathogenesis of psoriasis can be explained by dysregulation of immunological cell
function as well as keratinocyte proliferation/differentiation. Recently, the immunological …

The skin provides both a physical barrier and an immunologic barrier to external threats. The
protective machinery of the skin has evolved to provide situation-specific responses to …