Hepatocellular carcinoma (HCC), the primary malignancy of hepatocytes, is a diagnosis with
bleak outcome. According to National Cancer Institute's SEER database, the average five …

Hepatitis C virus (HCV) is a major cause of liver diseases including liver cirrhosis and
hepatocellular carcinoma. Approximately 3% of the world population is infected with HCV …

Kupffer cells are resident liver macrophages and play a critical role in maintaining liver
functions. Under physiological conditions, they are the first innate immune cells and protect …

Simple Summary An increasing number of cancer cases has been reported throughout the
years. Most cancers are linked to unhealthy lifestyles and genetic inheritance. Nevertheless …

To replicate their genomes in cells and generate new progeny, viruses typically require
factors provided by the cells that they have infected. Subversion of the cellular machinery …

Globally, over 500 million people are chronically infected with the hepatitis B virus (HBV) or
hepatitis C virus (HCV). These chronic infections cause liver inflammation, and may result in …

Hepatitis C virus (HCV) remains a global public health challenge with an estimated 71
million people chronically infected, with surges in new cases and no effective vaccine. New …

Hepatitis C virus (HCV) infection is a major public health concern, and almost two million
people are infected per year globally. This is occurred by the diverse spectrum of viral …

Infectious diseases still remain one of the biggest challenges for human health. Accurate
and early detection of infectious pathogens are crucial for transmission control, clinical …

This Review describes the increasing demand for organic synthesis to facilitate fragment-
based drug discovery (FBDD), focusing on polar, unprotected fragments. In FBDD, X-ray …