Same substrate, many reactions: oxygen activation in flavoenzymes
Over time, organisms have evolved strategies to cope with the abundance of dioxygen on
Earth. Oxygen-utilizing enzymes tightly control the reactions involving O2 mostly by …
Earth. Oxygen-utilizing enzymes tightly control the reactions involving O2 mostly by …
Oxidative cyclization in natural product biosynthesis
MC Tang, Y Zou, K Watanabe, CT Walsh… - Chemical …, 2017 - ACS Publications
Oxidative cyclizations are important transformations that occur widely during natural product
biosynthesis. The transformations from acyclic precursors to cyclized products can afford …
biosynthesis. The transformations from acyclic precursors to cyclized products can afford …
[HTML][HTML] Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus
Abstract Background The fungal genus Aspergillus is of critical importance to humankind.
Species include those with industrial applications, important pathogens of humans, animals …
Species include those with industrial applications, important pathogens of humans, animals …
Deciphering chemical logic of fungal natural product biosynthesis through heterologous expression and genome mining
Covering: 2010 to 2022 Heterologous expression of natural product biosynthetic gene
clusters (BGCs) has become a widely used tool for genome mining of cryptic pathways …
clusters (BGCs) has become a widely used tool for genome mining of cryptic pathways …
Navigating the fungal polyketide chemical space: from genes to molecules
The iterative type I polyketide synthases (IPKSs) are central to the biosynthesis of an
enormously diverse array of natural products in fungi. These natural products, known as …
enormously diverse array of natural products in fungi. These natural products, known as …
The biosynthesis of cytochalasans
E Skellam - Natural product reports, 2017 - pubs.rsc.org
Covering: up to 2017 Cytochalasans are a class of natural products possessing a wide
range of important biological activities, yet the full biosynthetic steps towards the formation of …
range of important biological activities, yet the full biosynthetic steps towards the formation of …
Molecular diversity sculpted by fungal PKS–NRPS hybrids
D Boettger, C Hertweck - ChemBioChem, 2013 - Wiley Online Library
Fungal polyketide synthase–nonribosomal peptide synthetase (PKS–NRPS) hybrids
manufacture a wide range of structurally diverse secondary metabolites that play an eminent …
manufacture a wide range of structurally diverse secondary metabolites that play an eminent …
[HTML][HTML] Biosynthesis of natural products by microbial iterative hybrid PKS–NRPS
KM Fisch - RSC advances, 2013 - pubs.rsc.org
Biosynthesis of natural products by microbial iterative hybrid PKS–NRPS - RSC Advances (RSC
Publishing) DOI:10.1039/C3RA42661K Royal Society of Chemistry View PDF VersionPrevious …
Publishing) DOI:10.1039/C3RA42661K Royal Society of Chemistry View PDF VersionPrevious …
Engineering the biosynthesis of fungal nonribosomal peptides
Covering: 2011 up to the end of 2021. Fungal nonribosomal peptides (NRPs) and the
related polyketide–nonribosomal peptide hybrid products (PK–NRPs) are a prolific source of …
related polyketide–nonribosomal peptide hybrid products (PK–NRPs) are a prolific source of …
Protein–protein interactions in polyketide synthase–nonribosomal peptide synthetase hybrid assembly lines
Covering: up to early 2018 Polyketides and nonribosomal peptides are two major families of
natural product with a broad range of biological activities. Polyketide synthases (PKSs) …
natural product with a broad range of biological activities. Polyketide synthases (PKSs) …