Since the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967,
our knowledge about the immunological mechanisms of IgE‐mediated allergies has …

Many allergens feature hydrophobic cavities that allow the binding of primarily hydrophobic
small‐molecule ligands. Ligand‐binding specificities can be strict or promiscuous. Serum …

There have been many attempts to identify common biophysical properties which
differentiate allergens from their non-immunogenic counterparts. This review will focus on …

Allergens from furry animals frequently cause sensitization and respiratory allergic diseases.
Most relevant mammalian respiratory allergens belong either to the protein family of …

Vicilin-buried peptides (VBPs) from edible plants are derived from the N-terminal leader
sequences (LSs) of seed storage proteins. VBPs are defined by a common α-hairpin fold …

Introduction Pet lipocalins are respiratory allergens with a central hydrophobic ligand-
binding cavity called a calyx. Molecules carried in the calyx by allergens are suggested to …

The mosquito protein AEG12 is up-regulated in response to blood meals and flavivirus
infection though its function remained elusive. Here, we determine the three-dimensional …

Purpose of Review A significant fraction of allergens bind small molecular ligands, and
many of these compounds are classified as lipids. However, in most cases, we do not know …

The cockroach allergen Bla g 1 encloses an exceptionally large hydrophobic cavity, which
allows it to bind and deliver unsaturated fatty acid ligands. Bla g 1-mediated delivery of …

From their expression in their respective allergenic source to their processing by antigen
presenting cells, allergens continuously encounter proteases. The ability of allergens to …