[HTML][HTML] Telomere-specific regulation of TERRA and its impact on telomere stability

J Rivosecchi, K Jurikova, E Cusanelli - Seminars in Cell & Developmental …, 2024 - Elsevier
TERRA is a class of telomeric repeat-containing RNAs that are expressed from telomeres in
multiple organisms. TERRA transcripts play key roles in telomere maintenance and their …

TERRA beyond cancer: the biology of telomeric repeat‐containing RNAs in somatic and germ cells

J Rivosecchi, E Cusanelli - Frontiers in Aging, 2023 - frontiersin.org
The telomeric noncoding RNA TERRA is a key component of telomeres and it is widely
expressed in normal as well as cancer cells. In the last 15 years, several publications have …

TERRA transcripts localize at long telomeres to regulate telomerase access to chromosome ends

N Bettin, E Querido, I Gialdini, GP Grupelli, E Goretti… - Science …, 2024 - science.org
The function of TERRA in the regulation of telomerase in human cells is still debated. While
TERRA interacts with telomerase, how it regulates telomerase function remains unknown …

TERRA expression is regulated by the telomere-binding proteins POT-1 and POT-2 in Caenorhabditis elegans

C Manzato, L Larini, C Oss Pegorar… - Nucleic Acids …, 2023 - academic.oup.com
Several aspects of telomere biology are regulated by the telomeric repeat-containing RNA
TERRA. While TERRA expression is conserved through evolution, species-specific …

TERRA ONTseq: a long-read-based sequencing pipeline to study the human telomeric transcriptome

J Rodrigues, R Alfieri, S Bione, CM Azzalin - RNA, 2024 - rnajournal.cshlp.org
The long noncoding RNA TERRA is transcribed from telomeres in virtually all eukaryotes
with linear chromosomes. In humans, TERRA transcription is driven in part by promoters …

TERRA and the alternative lengthening of telomeres: a dangerous affair

CM Azzalin - FEBS letters, 2024 - Wiley Online Library
Eukaryotic telomeres are transcribed into the long noncoding RNA TERRA. A fraction of
TERRA remains associated with telomeres by forming RNA: DNA hybrids dubbed telR …

[HTML][HTML] O-GlcNAcylated RALY Contributes to Hepatocellular Carcinoma Cells Proliferation by Regulating USP22 mRNA Nuclear Export

S Liu, Q Lv, X Mao, H Dong, W Xu, X Du… - … Journal of Biological …, 2024 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is one of the most prevalent and deadly tumors; however,
its pathogenic mechanism remains largely elusive. In-depth researches are needed to …

[HTML][HTML] Quantifying telomere transcripts as tool to improve risk assessment for genetic instability and genotoxicity

H Sutterlüty, M Bargl, K Holzmann - Mutation Research/Genetic Toxicology …, 2023 - Elsevier
Telomere repeat-containing RNAs (TERRA) are transcribed from telomeres as long non-
coding RNAs and are part of the telomere structure with protective function.(The genetic …

Telomeric lncRNA TERRA localizes to stress granules in human ALT cells

L Larini, E Goretti, E Zulian, E Busarello, SM Marino… - bioRxiv, 2024 - biorxiv.org
TERRA, the lncRNA derived from the ends of chromosomes, has a number of well-described
nuclear roles including telomere maintenance and homeostasis. A growing body of …

Investigating the roles of lncRNA TERRA in telomerase-to-ALT transition using cancer cell lines and multicellular organisms

C Oss Pegorar - 2024 - iris.unitn.it
Telomeres protect eukaryotic chromosomes from fusions and degradations and
progressively shorten over generations due to the “end replication problem” in human …