The initiation of DNA replication represents a committing step to cell proliferation.
Appropriate replication onset depends on multiprotein complexes that help properly …

Loading of the replicative DNA helicase at origins of replication is of central importance in
DNA replication. As the first of the replication fork proteins assemble at chromosomal origins …

Dedicated AAA+ ATPases deposit hexameric ring-shaped helicases onto DNA to promote
replication in cellular organisms. To understand how loading occurs, we used electron …

To initiate DNA replication, DnaA recognizes and binds to specific sequences within the
Escherichia coli chromosomal origin (oriC), and then unwinds a region within oriC. Next …

The year 2004 represents a milestone for the biosensor research community: in this year,
over 1000 articles were published describing experiments performed using commercially …

The loading of oligomeric helicases onto replication origins marks an essential step in
replisome assembly. In cells, dedicated AAA+ ATPases regulate loading, however, the …

Summary An AAA+ ATPase, DnaC, delivers DnaB helicase at the E. coli chromosomal origin
by a poorly understood process. This report shows that mutant proteins bearing alanine …

The initiation of chromosomal DNA replication starts at a replication origin, which in bacteria
is a discrete locus that contains DNA sequence motifs recognized by an initiator protein …

The evolution of bacterial regulatory circuits often involves duplication of genes encoding
transcription factors that may suffer both modifications in their detected signals, as well as …

Helicase loading at a DNA replication origin often requires the dynamic interactions
between the DNA helicase and an accessory protein. In E. coli, the DNA helicase is DnaB …