CCCTC‐binding factor (CTCF) is an eleven zinc finger (ZF), multivalent transcriptional
regulator, that recognizes numerous motifs thanks to the deployment of distinct combinations …

Structural variations (SVs) affect more of the cancer genome than any other type of somatic
genetic alteration but difficulties in detecting and interpreting them have limited our …

Colorectal malignancies are a leading cause of cancer-related death and have undergone
extensive genomic study,. However, DNA mutations alone do not fully explain malignant …

The human genome is organized into multiple structural layers, ranging from chromosome
territories to progressively smaller substructures, such as topologically associating domains …

Numerous pieces of evidence support the complex, 3D spatial organization of the genome
dictates gene expression. CTCF is essential to define topologically associated domain …

Faithful chromosome segregation is essential for the maintenance of genomic integrity and
requires functional centromeres. Centromeres are epigenetically defined by the histone H3 …

Hyperdiploidy, ie gain of whole chromosomes, is one of the most common genetic features
of childhood acute lymphoblastic leukemia (ALL), but its pathogenetic impact is poorly …

Background CTCF binding contributes to the establishment of a higher-order genome
structure by demarcating the boundaries of large-scale topologically associating domains …

With the rapid development of next-generation sequencing technology, chromosome
structural variation has gradually gained increased clinical significance in tumorigenesis …

Transcription is epigenetically regulated by the orchestrated function of chromatin-binding
proteins that tightly control the expression of master transcription factors, effectors, and …