Liver diseases are caused by different etiological agents, mainly alcohol consumption,
viruses, drug intoxication or malnutrition. Frequently, liver diseases are initiated by oxidative …

Distinct potassium, anion, and calcium channels in the plasma membrane and vacuolar
membrane of plant cells have been identified and characterized by patch clamping …

Stomatal complexes consist of pairs of guard cells and the pore they enclose. Reversible
changes in guard cell volume alter the aperture of the pore and provide the major regulatory …

Gas exchange in plants is controlled by guard cells, specialized cells acting as turgor
pressure‐driven valves. Malate is one of the major anions accumulated inside the vacuole …

Our research introduces the natural flavonoid naringenin as a novel inhibitor of an emerging
class of intracellular channels, Two-Pore Channel 2 (TPC2), as shown by …

The most prominent ion channel localized in plant vacuoles is the slow activating SV type.
Slow vacuolar (SV) channels were discovered by patch clamp studies as early as 1986. In …

Jasmonates, potent lipid mediators of defense gene expression in plants, are rapidly
synthesized in response to wounding. These lipid mediators also stimulate their own …

The central vacuole is the largest Ca2+ store in a mature plant cell. Ca2+ release from this
store contributes to Ca2+-mediated intracellular signalling in a variety of physiological …

Two-pore channel proteins (TPC) encode intracellular ion channels in both animals and
plants. In mammalian cells, the two isoforms (TPC1 and TPC2) localize to the endo …

Plant transformation protocols generally involve the use of selectable marker genes for the
screening of transgenic material. The bacterial gene nptII, coding for a neomycin …