Mineralocorticoid receptor antagonists in diabetic kidney disease—Mechanistic and therapeutic effects
Chronic kidney disease (CKD) is the leading complication in type 2 diabetes (T2D) and
current therapies that limit CKD progression and the development of cardiovascular disease …
current therapies that limit CKD progression and the development of cardiovascular disease …
Cardiac fibrosis: Cell biological mechanisms, molecular pathways and therapeutic opportunities
NG Frangogiannis - Molecular aspects of medicine, 2019 - Elsevier
Cardiac fibrosis is a common pathophysiologic companion of most myocardial diseases,
and is associated with systolic and diastolic dysfunction, arrhythmogenesis, and adverse …
and is associated with systolic and diastolic dysfunction, arrhythmogenesis, and adverse …
Immune mechanisms of hypertension
GR Drummond, A Vinh, TJ Guzik… - Nature Reviews …, 2019 - nature.com
Hypertension affects 30% of adults and is the leading risk factor for heart attack and stroke.
Traditionally, hypertension has been regarded as a disorder of two systems that are involved …
Traditionally, hypertension has been regarded as a disorder of two systems that are involved …
Hypertension: do inflammation and immunity hold the key to solving this epidemic?
Elevated cardiovascular risk including stroke, heart failure, and heart attack is present even
after normalization of blood pressure in patients with hypertension. Underlying immune cell …
after normalization of blood pressure in patients with hypertension. Underlying immune cell …
Hypertension, neurovascular dysfunction, and cognitive impairment
MM Santisteban, C Iadecola, D Carnevale - Hypertension, 2023 - Am Heart Assoc
Hypertension affects a significant proportion of the adult and aging population and
represents an important risk factor for vascular cognitive impairment and late-life dementia …
represents an important risk factor for vascular cognitive impairment and late-life dementia …
High-fiber diet and acetate supplementation change the gut microbiota and prevent the development of hypertension and heart failure in hypertensive mice
FZ Marques, E Nelson, PY Chu, D Horlock, A Fiedler… - Circulation, 2017 - Am Heart Assoc
Background: Dietary intake of fruit and vegetables is associated with lower incidence of
hypertension, but the mechanisms involved have not been elucidated. Here, we evaluated …
hypertension, but the mechanisms involved have not been elucidated. Here, we evaluated …
Aldosterone, inflammation, immune system, and hypertension
Aldosterone is a mineralocorticoid hormone that controls body fluid and electrolyte balance.
Excess aldosterone is associated with cardiovascular and metabolic diseases. Inflammation …
Excess aldosterone is associated with cardiovascular and metabolic diseases. Inflammation …
Role of the immune system in hypertension
B Rodriguez-Iturbe, H Pons… - Physiological …, 2017 - journals.physiology.org
High blood pressure is present in more than one billion adults worldwide and is the most
important modifiable risk factor of death resulting from cardiovascular disease. While many …
important modifiable risk factor of death resulting from cardiovascular disease. While many …
Inflammation, immunity, and hypertensive end-organ damage
For> 50 years, it has been recognized that immunity contributes to hypertension. Recent
data have defined an important role of T cells and various T cell–derived cytokines in …
data have defined an important role of T cells and various T cell–derived cytokines in …
The immunology of hypertension
Although systemic hypertension affects a large proportion of the population, its etiology
remains poorly defined. Emerging evidence supports the concept that immune cells become …
remains poorly defined. Emerging evidence supports the concept that immune cells become …