Aging has been linked to several degenerative processes that, through the accumulation of
molecular and cellular damage, can progressively lead to cell dysfunction and organ failure …

Maximum life span differences among animal species exceed life span variation achieved
by experimental manipulation by orders of magnitude. The differences in the characteristic …

An updated version of the mitochondrial free radical theory of aging (MFRTA) and longevity
is reviewed. Key aspects of the theory are emphasized. Another main focus concerns …

The reduction of oxidative stress could be achieved in three levels: by lowering exposure to
environmental pollutants with oxidizing properties, by increasing levels of endogenous and …

Oxygen has had extraordinary effects on life. Three hundred million years ago, in
Carboniferous times, dragonflies grew as big as seagulls, with wingspans ofnearly a metre …

Tremendous variation in maximum life span among species overshadows modest increases
in longevity resulting from experimental manipulation. Few aging studies focus on long-lived …

Studies in heart and nonsynaptic brain mitochondria from two mammals and three birds
showthat complex I generates oxygen radicals in heart and nonsynaptic brain mitochondria …

Nonenzymatic molecular modifications induced by reactive carbonyl species (RCS)
generated by peroxidation of membrane phospholipids acyl chains play a causal role in the …

Abstract Glutathione peroxidase 4 (GP x4) is the only enzyme capable of reducing toxic lipid
hydroperoxides in biological membranes to the corresponding alcohols using glutathione as …

Harman first suggested in 1972 that mitochondria might be the biological clock in aging,
noting that the rate of oxygen consumption should determine the rate of accumulation of …