G protein–coupled receptors are the largest and pharmacologically most important receptor
family and are involved in the regulation of most cell functions. Most of them reside …

G protein-coupled receptors (GPCRs) are the largest family of cell surface receptors and a
critical class of regulators of mammalian physiology. Also known as seven transmembrane …

G protein-coupled receptors (GPCRs), the largest family of human membrane proteins and
an important class of drug targets, play a role in maintaining numerous physiological …

Gprotein-coupled receptors (GPCRs) regulate several physiological and pathological
processes and represent the target of approximately 30% of Food and Drug Administration …

G protein-coupled receptors (GPCRs) are ligand-activated cell membrane proteins and
represent the most important class of drug targets. GPCRs adopt several active …

The μ-opioid receptor (μOR), a prototypical G protein-coupled receptor (GPCR), is the target
of opioid analgesics such as morphine and fentanyl. Due to the severe side effects of current …

ABSTRACT G protein-coupled receptors (GPCRs) are the largest class of transmembrane
receptors encoded in the human genome, and they initiate cellular responses triggered by a …

The prevention and treatment of addiction (moderate to severe substance use disorder—
SUD) have remained challenging because of the dynamic and complex interactions …

During Hedgehog (Hh) signal transduction in development and disease, the atypical G
protein-coupled receptor (GPCR) SMOOTHENED (SMO) communicates with GLI …

Peptides mediate cancer progression favoring the mitogenesis, migration, and invasion of
tumor cells, promoting metastasis and anti-apoptotic mechanisms, and facilitating …