Three-dimensional spheroids as in vitro preclinical models for cancer research
Most cancer biologists still rely on conventional two-dimensional (2D) monolayer culture
techniques to test in vitro anti-tumor drugs prior to in vivo testing. However, the vast majority …
techniques to test in vitro anti-tumor drugs prior to in vivo testing. However, the vast majority …
Spheroids as a type of three-dimensional cell cultures—examples of methods of preparation and the most important application
K Białkowska, P Komorowski, M Bryszewska… - International journal of …, 2020 - mdpi.com
Cell cultures are very important for testing materials and drugs, and in the examination of
cell biology and special cell mechanisms. The most popular models of cell culture are two …
cell biology and special cell mechanisms. The most popular models of cell culture are two …
Magnetic torque–driven living microrobots for increased tumor infiltration
Biohybrid bacteria–based microrobots are increasingly recognized as promising externally
controllable vehicles for targeted cancer therapy. Magnetic fields in particular have been …
controllable vehicles for targeted cancer therapy. Magnetic fields in particular have been …
Modelling cancer in microfluidic human organs-on-chips
A Sontheimer-Phelps, BA Hassell, DE Ingber - Nature Reviews Cancer, 2019 - nature.com
One of the problems that has slowed the development and approval of new anticancer
therapies is the lack of preclinical models that can be used to identify key molecular, cellular …
therapies is the lack of preclinical models that can be used to identify key molecular, cellular …
3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs
AS Nunes, AS Barros, EC Costa… - Biotechnology and …, 2019 - Wiley Online Library
Three‐dimensional cell culture models, such as spheroids, can be used in the process of the
development of new anticancer agents because they are able to closely mimic the main …
development of new anticancer agents because they are able to closely mimic the main …
Modeling neoplastic disease with spheroids and organoids
Cancer is a complex disease in which both genetic defects and microenvironmental
components contribute to the development, progression, and metastasization of disease …
components contribute to the development, progression, and metastasization of disease …
Engineering nanocellulose hydrogels for biomedical applications
Nanocellulose hydrogels are highly hydrated porous cellulosic soft materials with good
mechanical properties. These cellulose-based gels can be produced from bacterial or plant …
mechanical properties. These cellulose-based gels can be produced from bacterial or plant …
Advances in Spheroids and Organoids on a Chip
Multicellular spheroids and organoids are promising in vitro 3D models in personalized
medicine and drug screening. They replicate the structural and functional characteristics of …
medicine and drug screening. They replicate the structural and functional characteristics of …
Microfluidics for drug development: from synthesis to evaluation
Drug development is a long process whose main content includes drug synthesis, drug
delivery, and drug evaluation. Compared with conventional drug development procedures …
delivery, and drug evaluation. Compared with conventional drug development procedures …
Three-dimensional culture systems in cancer research: Focus on tumor spheroid model
Cancer cells propagated in three-dimensional (3D) culture systems exhibit physiologically
relevant cell–cell and cell–matrix interactions, gene expression and signaling pathway …
relevant cell–cell and cell–matrix interactions, gene expression and signaling pathway …