ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in ageing,
affecting around 46 million people worldwide but few treatments are currently available. The …

Astrocytes, the most abundant glial cells in the mammalian brain, are critical regulators of
brain development and physiology through dynamic and often bidirectional interactions with …

Dietary polyphenols have been the focus of major interest for their potential benefits on
human health. Several preclinical studies have been conducted to provide a rationale for …

Background The growing body of evidence indicating the heterogeneity of Alzheimer's
disease (AD), coupled with disappointing clinical studies directed at a fit-for-all therapy …

Traumatic brain injuries (TBIs) are clinically grouped by severity: mild, moderate and severe.
Mild TBI (the least severe form) is synonymous with concussion and is typically caused by …

Amyloid-beta (Aß) and hyperphosphorylated tau are hallmark lesions of Alzheimer's disease
(AD). However, the loss of synapses and dysfunctions of neurotransmission are more …

Background and Objectives The goal of this work was to investigate the natural history and
outcomes after treatment for spontaneous amyloid-related imaging abnormalities (ARIA)-like …

The production of soluble amyloid-β oligomers (AβOs) and the activation of inflammation are
two important early steps in the pathogenesis of Alzheimer's disease (AD). The central role …

The strongest genetic risk factor influencing susceptibility to late-onset Alzheimer's disease
(AD) is apolipoprotein E (APOE) genotype. APOE has three common isoforms in humans …