Selenium is an essential micronutrient with important functions in human health and
relevance to several pathophysiological conditions. The biological effects of selenium are …

The human selenoprotein family contains 25 members that share the common feature of
containing the amino acid, selenocysteine (Sec). Seven selenoproteins are localized to the …

Although selenocysteine selenenic acids (Sec–SeOHs) have been recognized as key
intermediates in the catalytic cycle of glutathione peroxidase (GPx), examples of the direct …

Selenium is an essential trace element with growth‐modulating properties. Decades of
research clearly demonstrate that selenium compounds inhibit the growth of malignant cells …

Abstract Selenocysteine (Sec), the 21st genetically encoded amino acid, is structurally
similar to cysteine (Cys) but with a sulfur to selenium replacement. This small change …

Chronic metabolic stress leads to cellular dysfunction, characterized by excessive reactive
oxygen species, endoplasmic reticulum (ER) stress and inflammation, which has been …

Cytosolic valosin-containing protein (p97 (VCP)) is translocated to the ER membrane by
binding to selenoprotein S (SelS), which is an ER membrane protein, during endoplasmic …

Highlights•Selenocysteine endows proteins with novel redox properties.•New recombinant
and chemical methods are facilitating selenoprotein production.•Many natural …

Selenocysteine is a catalytic residue at the active site of all selenoenzymes in bacteria and
mammals, and it is incorporated into the polypeptide backbone by a co-translational process …

Selenoprotein S (selenos) is a small, intrinsically disordered membrane protein that is
associated with various cellular functions, such as inflammatory processes, cellular stress …