Liposomes and extracellular vesicles as drug delivery systems: A comparison of composition, pharmacokinetics, and functionalization

L van der Koog, TB Gandek… - Advanced healthcare …, 2022 - Wiley Online Library
Over the past decades, lipid‐based nanoparticle drug delivery systems (DDS) have caught
the attention of researchers worldwide, encouraging the field to rapidly develop improved …

Synthetic biology: bottom-up assembly of molecular systems

S Hirschi, TR Ward, WP Meier, DJ Müller… - Chemical …, 2022 - ACS Publications
The bottom-up assembly of biological and chemical components opens exciting
opportunities to engineer artificial vesicular systems for applications with previously unmet …

Role of the lipid bilayer in outer membrane protein folding in Gram-negative bacteria

JE Horne, DJ Brockwell, SE Radford - Journal of Biological Chemistry, 2020 - ASBMB
β-Barrel outer membrane proteins (OMPs) represent the major proteinaceous component of
the outer membrane (OM) of Gram-negative bacteria. These proteins perform key roles in …

Different pathways for engulfment and endocytosis of liquid droplets by nanovesicles

R Ghosh, V Satarifard, R Lipowsky - Nature Communications, 2023 - nature.com
During endocytosis of nanoparticles by cells, the cellular membranes engulf the particles,
thereby forming a closed membrane neck that subsequently undergoes fission. For solid …

[HTML][HTML] Physiological roles of transverse lipid asymmetry of animal membranes

RJ Clarke, KR Hossain, K Cao - Biochimica et Biophysica Acta (BBA) …, 2020 - Elsevier
The plasma membrane phospholipid distribution of animal cells is markedly asymmetric.
Phosphatidylserine (PS) and phosphatidylethanolamine (PE) are concentrated in the inner …

Liposomes as biomembrane models: Biophysical techniques for drug-membrane interaction studies

S Andrade, MJ Ramalho, JA Loureiro… - Journal of molecular …, 2021 - Elsevier
The interaction of drugs with biological membranes is a critical factor affecting their
pharmacokinetics and pharmacodynamics, so understanding how drugs interact with …

Insights into asymmetric liposomes as a potential intervention for drug delivery including pulmonary nanotherapeutics

YN Al Badri, CS Chaw, AA Elkordy - Pharmaceutics, 2023 - mdpi.com
Liposome-based drug delivery systems are nanosized spherical lipid bilayer carriers that
can encapsulate a broad range of small drug molecules (hydrophilic and hydrophobic …

Poly (Sarcosine) Surface Modification Imparts Stealth‐Like Properties to Liposomes

S Bleher, J Buck, C Muhl, S Sieber, S Barnert… - Small, 2019 - Wiley Online Library
Circulation lifetime is a crucial parameter for a successful therapy with nanoparticles.
Reduction and alteration of opsonization profiles by surface modification of nanoparticles is …

Membrane structure–function insights from asymmetric lipid vesicles

E London - Accounts of chemical research, 2019 - ACS Publications
Conspectus The lipid bilayer, together with embedded proteins, is the central structure in
biomembranes. While artificial lipid bilayers are useful to model natural membranes, they …

Leaflet tensions control the spatio-temporal remodeling of lipid bilayers and nanovesicles

R Lipowsky, R Ghosh, V Satarifard, A Sreekumari… - Biomolecules, 2023 - mdpi.com
Biological and biomimetic membranes are based on lipid bilayers, which consist of two
monolayers or leaflets. To avoid bilayer edges, which form when the hydrophobic core of …