Continuous Renal Replacement Therapy (CRRT) is more and more widely used in patients
for various indications recent years. It is still intricate for clinicians to decide a suitable …

What is known and objective Meropenem, a carbapenem antibiotic, is widely prescribed for
the treatment of life‐threatening infections. The main parameter associated with its …

Innovative treatment modalities have not yet shown a clinical benefit in patients with septic
shock. To reduce severe cytokinaemia, CytoSorb as an add-on to continuous renal …

Our aim was to investigate continuous renal replacement therapy (CRRT) with CytoSorb
cartridge for patients with life‐threatening COVID‐19 plus acute kidney injury (AKI), sepsis …

Purpose Augmented renal clearance (ARC) is common in critically ill patients and may lead
to subtherapeutic levels of antibiotics, thus influencing clinical outcomes and emergence of …

Objective Unpredictable pharmacokinetics of antibiotics in patients with life-threatening
bacterial infections is associated with drug under-or overdosing. Therapeutic drug …

Objective To determine whether established ceftolozane/tazobactam (C/T) dosing is
adequate for patients with augmented renal clearance (ARC) and bacterial infection …

Population pharmacokinetic (popPK) approaches have spread widely throughout clinical
pharmacology research, and every clinician should have some understanding of them. After …

Early initiation of effective antibiotic therapy is vitally important for saving the lives of critically
ill patients with sepsis or septic shock. The susceptibility of the infecting pathogen and the …

Purpose This study aimed to develop a population pharmacokinetic (PPK) model for
meropenem to optimize dosing regimens for critically ill patients with pulmonary infection …