Follicular helper T (TFH) cells provide help to B cells, supporting the formation of germinal
centres that allow affinity maturation of antibody responses. Although usually located in …

Dendritic cells are powerful antigen-presenting cells that are essential for the priming of T
cell responses. In addition to providing T-cell-receptor ligands and co-stimulatory molecules …

We employed scRNA sequencing to extensively characterize the cellular landscape of
human liver from development to disease. Analysis of∼ 212,000 cells representing human …

The identification of CD4+ T cells localizing to B cell follicles has revolutionized the
knowledge of how humoral immunity is generated. Follicular helper T (TFH) cells support …

Summary Foxp3+ T regulatory (Treg) cells promote immunological tumor tolerance, but how
their immune-suppressive function is regulated in the tumor microenvironment (TME) …

Foxp3-expressing CD4+ CD25+ regulatory T cells (Tregs) constitutively and highly express
the immune checkpoint receptor cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) …

Therapeutic targeting of immune checkpoints has garnered significant attention in the area
of cancer immunotherapy, in which efforts have focused in particular on cytotoxic T …

Tumor-draining lymph node (TDLN) invasion by metastatic cells in breast cancer correlates
with poor prognosis and is associated with local immunosuppression, which can be partly …

Dendritic cells (DCs) mature in an immunogenic or tolerogenic manner depending on the
context in which an antigen is perceived, preserving the balance between immunity and …

Patients with cancer with liver metastasis demonstrate significantly worse outcomes than
those without liver metastasis when treated with anti–PD-1 immunotherapy. The mechanism …