SCN VIP neurons are essential for normal light-mediated resetting of the circadian system

JR Jones, T Simon, L Lones… - Journal of …, 2018 - Soc Neuroscience
The suprachiasmatic nucleus (SCN) synchronizes circadian rhythms in behavior and
physiology to the external light cycle, but the mechanisms by which this occurs are unclear …

In vivo recording of suprachiasmatic nucleus dynamics reveals a dominant role of arginine vasopressin neurons in circadian pacesetting

Y Tsuno, Y Peng, S Horike, M Wang, A Matsui… - PLoS …, 2023 - journals.plos.org
The central circadian clock of the suprachiasmatic nucleus (SCN) is a network consisting of
various types of neurons and glial cells. Individual cells have the autonomous molecular …

Reviewing evidence for the relationship of EEG abnormalities and RTT phenotype paralleled by insights from animal studies

K Smirnov, T Stroganova, S Molholm… - International Journal of …, 2021 - mdpi.com
Rett syndrome (RTT) is a rare neurodevelopmental disorder that is usually caused by
mutations of the MECP2 gene. Patients with RTT suffer from severe deficits in motor …

Vasoactive intestinal peptide controls the suprachiasmatic circadian clock network via ERK1/2 and DUSP4 signalling

R Hamnett, P Crosby, JE Chesham… - Nature …, 2019 - nature.com
The suprachiasmatic nucleus (SCN) co-ordinates circadian behaviour and physiology in
mammals. Its cell-autonomous circadian oscillations pivot around a well characterised …

Light/clock influences membrane potential dynamics to regulate sleep states

M Tabuchi, KE Coates, OB Bautista… - Frontiers in …, 2021 - frontiersin.org
The circadian rhythm is a fundamental process that regulates the sleep–wake cycle. This
rhythm is regulated by core clock genes that oscillate to create a physiological rhythm of …

In vivo recording of the circadian calcium rhythm in Prokineticin 2 neurons of the suprachiasmatic nucleus

K Onodera, Y Tsuno, Y Hiraoka, K Tanaka… - Scientific Reports, 2023 - nature.com
Abstract Prokineticin 2 (Prok2) is a small protein expressed in a subpopulation of neurons in
the suprachiasmatic nucleus (SCN), the primary circadian pacemaker in mammals. Prok2 …

[HTML][HTML] Immediate responses to ambient light in vivo reveal distinct subpopulations of suprachiasmatic VIP neurons

A Kahan, K Mahe, S Dutta, P Kassraian, A Wang… - Iscience, 2023 - cell.com
The circadian rhythm pacemaker, the suprachiasmatic nucleus (SCN), mediates light
entrainment via vasoactive intestinal peptide (VIP) neurons (SCN VIP). Yet, how these …

[HTML][HTML] Drastic decline in vasoactive intestinal peptide expression in the suprachiasmatic nucleus in obese mice on a long-term high-fat diet

D Afonso-Oramas, L Santana-Cordón… - Brain Research …, 2023 - Elsevier
The suprachiasmatic nucleus (SCN) is the main region for the regulation of circadian
rhythms. Although the SCN contains a heterogeneous neurochemical phenotype with a …

An LHX1-regulated transcriptional network controls sleep/wake coupling and thermal resistance of the central circadian clockworks

JL Bedont, TA LeGates, E Buhr, A Bathini, JP Ling… - Current Biology, 2017 - cell.com
The suprachiasmatic nucleus (SCN) is the central circadian clock in mammals. It is entrained
by light but resistant to temperature shifts that entrain peripheral clocks [1–5]. The SCN …

Resynchronization dynamics reveal that the ventral entrains the dorsal suprachiasmatic nucleus

SR Taylor, TJ Wang… - Journal of …, 2017 - journals.sagepub.com
Although the suprachiasmatic nucleus (SCN) has long been considered the master
circadian clock in mammals, the topology of the connections that synchronize daily rhythms …