[HTML][HTML] The Pivotal Role of Preclinical Animal Models in Anti-Cancer Drug Discovery and Personalized Cancer Therapy Strategies
H Guo, X Xu, J Zhang, Y Du, X Yang, Z He, L Zhao… - Pharmaceuticals, 2024 - mdpi.com
The establishment and utilization of preclinical animal models constitute a pivotal aspect
across all facets of cancer research, indispensably contributing to the comprehension of …
across all facets of cancer research, indispensably contributing to the comprehension of …
[HTML][HTML] PMMA nanoplastics induce gastric epithelial cellular senescence and cGAS-STING-mediated inflammation via ROS overproduction and NHEJ suppression
X Li, Y Huang, D Zu, H Liu, H He, Q Bao, Y He… - Ecotoxicology and …, 2024 - Elsevier
The increasing environmental presence of nanoplastics (NPs) has raised concerns about
their potential impact on biological systems. We investigated the repercussions of …
their potential impact on biological systems. We investigated the repercussions of …
PARP inhibitor resistance mechanisms and PARP inhibitor derived imaging probes
T Yu, BH Lok - Expert Review of Anticancer Therapy, 2024 - Taylor & Francis
Introduction Poly (ADP-ribose) polymerase 1 (PARP1) inhibition has become a major target
in anticancer therapy. While PARP inhibitors (PARPi) are approved for homologous …
in anticancer therapy. While PARP inhibitors (PARPi) are approved for homologous …
Disparate requirements for RAD54L in replication fork reversal
ME Uhrig, N Sharma, P Maxwell, J Gomez… - Nucleic acids …, 2024 - academic.oup.com
Abstract RAD54L is a DNA motor protein with multiple roles in homologous recombination
DNA repair. In vitro, RAD54L was shown to also catalyze the reversal and restoration of …
DNA repair. In vitro, RAD54L was shown to also catalyze the reversal and restoration of …
[HTML][HTML] A goldilocks computational protocol for inhibitor discovery targeting DNA damage responses including replication-repair functions
While many researchers can design knockdown and knockout methodologies to remove a
gene product, this is mainly untrue for new chemical inhibitor designs that empower …
gene product, this is mainly untrue for new chemical inhibitor designs that empower …
The role of GRB2 in diabetes, diabetes complications and related disorders
J Ma, Y Dong, J Liu, S Gao, J Quan - Diabetes, Obesity and … - Wiley Online Library
Growth factor receptor‐bound protein 2 (GRB2) is a key adaptor protein involved in multiple
signalling pathways, and its dysregulation is associated with various diseases. Type 2 …
signalling pathways, and its dysregulation is associated with various diseases. Type 2 …
[HTML][HTML] Enriched G4 forming repeats in the human genome are associated with robust well-coordinated transcription and reduced cancer transcriptome variation
Non-B DNA G-quadruplex (G4) structures with guanine (G) runs of 2 to 4 repeats can trigger
opposing experimental transcriptional impacts. Here, we used bioinformatic algorithms to …
opposing experimental transcriptional impacts. Here, we used bioinformatic algorithms to …