Small heat shock proteins (sHsps) are conserved across species and are important in stress
tolerance. Many sHsps exhibit chaperone-like activity in preventing aggregation of target …

Substantial evidence links α-synuclein, a small highly conserved presynaptic protein with
unknown function, to both familial and sporadic Parkinson's disease (PD). α-Synuclein has …

Parkinson disease (PD) is an age-related neurodegenerative disorder that affects as many
as 1–2% of persons aged 60 years and older. With the aging of the population, the …

The accumulation of α-synuclein aggregates is the hallmark of Parkinson's disease, and
more generally of synucleinopathies. The accumulation of tau aggregates however is …

The sirtuins are members of the histone deacetylase family of proteins that participate in a
variety of cellular functions and play a role in aging. We identified a potent inhibitor of sirtuin …

Modern classification of the family of human small heat shock proteins (the so-called HSPB)
is presented, and the structure and properties of three members of this family are analyzed …

Background Misfolding, oligomerization, and fibrillization of α-synuclein are thought to be
central events in the onset and progression of Parkinson's disease (PD) and related …

Aberrant accumulation of misfolded proteins into amyloid deposits is a hallmark in many age-
related neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's …

Emerging evidence indicates that heat shock proteins (HSPs) are critical regulators in
normal neural physiological function as well as in cell stress responses. The functions of …

Accumulation of pathological α-synuclein aggregates plays a major role in Parkinson's
disease. Macroautophagy is a mechanism to degrade intracellular protein aggregates by …