The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is a key regulator of
the cellular antioxidant response, controlling the expression of genes that counteract …

Significance: Iron and oxygen are intimately linked: iron is an essential nutrient utilized as a
cofactor in enzymes for oxygen transport, oxidative phosphorylation, and metabolite …

Abstract The Keap1–Nrf2–ARE ((Kelch‐like ECH‐Associating protein 1) nuclear factor
erythroid 2 related factor 2‐antioxidant response element) pathway is one of the most …

Hepatocellular carcinoma is the most prevalent form of primary liver cancer with a
multifactorial aetiology comprising genetic, environmental, and behavioural factors. Evading …

Cellular oxidative and electrophilic stress triggers a protective response in mammals
regulated by NRF2 (nuclear factor (erythroid-derived) 2-like; NFE2L2) binding to …

Abstract The Keap1–Nrf2–ARE pathway is an important antioxidant defense mechanism that
protects cells from oxidative stress and the Keap1–Nrf2 protein–protein interaction (PPI) has …

Ferroptosis is an iron-dependent and lipid peroxidation-driven cell death cascade, occurring
when there is an imbalance of redox homeostasis in the cell. Nuclear factor erythroid 2 …

Atherosclerosis (AS) is a major cause of cardiovascular diseases such as coronary heart
disease, heart failure and stroke. Abnormal lipid metabolism, oxidative stress and …

Fumarate hydratase (FH) mutation causes hereditary type 2 papillary renal cell carcinoma
(PRCC2). The main effect of FH mutation is fumarate accumulation. The current paradigm …

The incidence of lung diseases and cancer caused by cigarette smoke is increasing. The
molecular mechanisms of gene regulation induced by cigarette smoke that ultimately lead to …