Fibrosis can affect any organ and is responsible for up to 45% of all deaths in the
industrialized world. It has long been thought to be relentlessly progressive and irreversible …

In chronic infection, inflammation and cancer, the tissue microenvironment controls how
local immune cells behave, with tissue-resident fibroblasts emerging as a key cell type in …

Chronic kidney disease (CKD) is a devastating condition that is reaching epidemic levels
owing to the increasing prevalence of diabetes mellitus, hypertension and obesity, as well …

Although systemic hypertension affects a large proportion of the population, its etiology
remains poorly defined. Emerging evidence supports the concept that immune cells become …

Fibrosis is caused by extensive deposition of extracellular matrix (ECM) components, which
play a crucial role in injury repair. Fibrosis attributes to~ 45% of all deaths worldwide. The …

IL-17 (IL-17A) is a pro-inflammatory cytokine produced by a sub-set of T helper cells termed
Th17 cells primarily in response to cytokines like TGF-β and IL-23 and play an important role …

Chronic kidney disease (CKD) is one of the major health problems of the modern age. It
represents an important public health challenge with an ever-lasting rising prevalence …

Complement synthesis in cells of origin is strongly linked to the pathogenesis and
progression of renal disease. Multiple studies have examined local C3 synthesis in renal …

Based on high quality surgery and scientific data, scientists and surgeons are committed to
protecting patients as well as healthcare staff and hereby provide this Guidance to address …

Hypertension is now considered as an inflammatory disease, and the kidney is a key end-
organ target. Experimental and clinical studies suggest that interleukin 17A (IL-17A) is a …