Predicting the effects of mutations in proteins is critical to many applications, from
understanding genetic disease to designing novel proteins to address our most pressing …

Advances in protein engineering-enabled enzyme immobilization technologies have
significantly improved enzyme–electrode wiring in enzymatic electrochemical systems …

Predicting the effects of mutations in proteins is critical to many applications, from
understanding genetic disease to designing novel proteins that can address our most …

Recent work from Nguyen et al. unveils massively parallel measurements of epistatic
interactions between two enzymes, dihydrofolate reductase and thymidylate synthase, in …

Aim This study aims to compare the efficiencies and toxicities of pegylated liposomal
doxorubicin (PLD) based and epirubicin based chemotherapeutic regimens as neoadjuvant …

Predicting the functional impact of changes to biological sequences is a central challenge in
genetics and biology. Beyond genetics, sequence-to-function mapping has key applications …

Multiplexed assays of variant effects (MAVEs) make it possible to measure the functional
impact of all possible single amino acid residue substitutions in a protein in a single …

Millenia of evolutionary experiments have produced an extensive universe of natural
macromolecular machines-proteins-that perform the variety of complex functions needed to …