[HTML][HTML] Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study
H Yu, L Lin, Z Zhang, H Zhang, H Hu - Signal transduction and targeted …, 2020 - nature.com
NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is
activated by various stimuli, transducing a quick but transient transcriptional activity, to …
activated by various stimuli, transducing a quick but transient transcriptional activity, to …
The TNF family of ligands and receptors: communication modules in the immune system and beyond
C Dostert, M Grusdat, E Letellier… - Physiological …, 2019 - journals.physiology.org
The tumor necrosis factor (TNF) and TNF receptor (TNFR) superfamilies (TNFSF/TNFRSF)
include 19 ligands and 29 receptors that play important roles in the modulation of cellular …
include 19 ligands and 29 receptors that play important roles in the modulation of cellular …
A cell atlas of human thymic development defines T cell repertoire formation
JE Park, RA Botting, C Domínguez Conde… - Science, 2020 - science.org
INTRODUCTION The thymus is the critical organ for T cell development and T cell receptor
(TCR) repertoire formation, which shapes the landscape of adaptive immunity. T cell …
(TCR) repertoire formation, which shapes the landscape of adaptive immunity. T cell …
Osteoimmunology: the conceptual framework unifying the immune and skeletal systems
K Okamoto, T Nakashima, M Shinohara… - Physiological …, 2017 - journals.physiology.org
The immune and skeletal systems share a variety of molecules, including cytokines,
chemokines, hormones, receptors, and transcription factors. Bone cells interact with immune …
chemokines, hormones, receptors, and transcription factors. Bone cells interact with immune …
[HTML][HTML] T cell regeneration after immunological injury
Following periods of haematopoietic cell stress, such as after chemotherapy, radiotherapy,
infection and transplantation, patient outcomes are linked to the degree of immune …
infection and transplantation, patient outcomes are linked to the degree of immune …
[HTML][HTML] Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla
JL Bautista, NT Cramer, CN Miller, J Chavez… - Nature …, 2021 - nature.com
The thymus' key function in the immune system is to provide the necessary environment for
the development of diverse and self-tolerant T lymphocytes. While recent evidence suggests …
the development of diverse and self-tolerant T lymphocytes. While recent evidence suggests …
[HTML][HTML] Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency
Patients with autoimmune polyendocrinopathy syndrome type 1 (APS-1) caused by
autosomal recessive AIRE deficiency produce autoantibodies that neutralize type I …
autosomal recessive AIRE deficiency produce autoantibodies that neutralize type I …
Interleukin-22: immunobiology and pathology
JA Dudakov, AM Hanash… - Annual review of …, 2015 - annualreviews.org
Interleukin-22 (IL-22) is a recently described IL-10 family cytokine that is produced by T
helper (Th) 17 cells, γδ T cells, NKT cells, and newly described innate lymphoid cells (ILCs) …
helper (Th) 17 cells, γδ T cells, NKT cells, and newly described innate lymphoid cells (ILCs) …
[HTML][HTML] RANKL biology: bone metabolism, the immune system, and beyond
T Ono, M Hayashi, F Sasaki, T Nakashima - Inflammation and …, 2020 - Springer
Receptor activator of NF-κB (RANK) ligand (RANKL) induces the differentiation of monocyte/
macrophage–lineage cells into the bone–resorbing cells called osteoclasts. Because …
macrophage–lineage cells into the bone–resorbing cells called osteoclasts. Because …
RANKL biology
N Takegahara, H Kim, Y Choi - Bone, 2022 - Elsevier
Since the receptor activator of nuclear factor-kappa B ligand (RANKL), its cognate receptor
activator of nuclear factor-kappa B (RANK), and the decoy receptor osteoprotegerin (OPG) …
activator of nuclear factor-kappa B (RANK), and the decoy receptor osteoprotegerin (OPG) …