Objectives The National Institutes of Health, led by the National Heart, Lung, and Blood
Institute, organized a working group of experts to discuss the problem of weight regain after …

Dieting is the most common approach to losing weight for the majority of obese and
overweight individuals. Restricting intake leads to weight loss in the short term, but, by itself …

Background After weight loss, changes in the circulating levels of several peripheral
hormones involved in the homeostatic regulation of body weight occur. Whether these …

Weight regain after weight loss is a substantial challenge in obesity therapeutics. Dieting
leads to significant adaptations in the homeostatic system that controls body weight, which …

Maintenance of a reduced body weight is accompanied by a decrease in energy
expenditure beyond that accounted for by reduced body mass and composition, as well as …

The intent of this paper is to address the obesity epidemic, which is a term used to describe
the sudden and rapid increase in obesity rates that began in the 1980s and continues …

The persistence of an epidemic of obesity and type 2 diabetes suggests that new nutritional
strategies are needed if the epidemic is to be overcome. A promising nutritional approach …

Maintenance of a reduced body weight is accompanied by decreased energy expenditure
that is due largely to increased skeletal muscle work efficiency. In addition, decreased …

Increased hunger and food intake during attempts to maintain weight loss are a critical
problem in clinical management of obesity. To determine whether reduced body weight …

In recent years, we've developed a much better grasp of the biological and other factors
associated with the development of obesity. Reflecting our evolving understanding of …