Fighting antibiotic resistance—strategies and (pre) clinical developments to find new antibacterials

S Walesch, J Birkelbach, G Jézéquel, FPJ Haeckl… - EMBO …, 2023 - embopress.org
Antibacterial resistance is one of the greatest threats to human health. The development of
new therapeutics against bacterial pathogens has slowed drastically since the approvals of …

The value of antimicrobial peptides in the age of resistance

M Magana, M Pushpanathan, AL Santos… - The lancet infectious …, 2020 - thelancet.com
Accelerating growth and global expansion of antimicrobial resistance has deepened the
need for discovery of novel antimicrobial agents. Antimicrobial peptides have clear …

[HTML][HTML] Natural products in drug discovery: advances and opportunities

AG Atanasov, SB Zotchev, VM Dirsch… - Nature reviews Drug …, 2021 - nature.com
Natural products and their structural analogues have historically made a major contribution
to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural …

Plant natural flavonoids against multidrug resistant pathogens

M Song, Y Liu, T Li, X Liu, Z Hao, S Ding… - Advanced …, 2021 - Wiley Online Library
The increasing emergence and dissemination of multidrug resistant (MDR) bacterial
pathogens accelerate the desires for new antibiotics. Natural products dominate the …

Computational identification of a systemic antibiotic for gram-negative bacteria

RD Miller, A Iinishi, SM Modaresi, BK Yoo… - Nature …, 2022 - nature.com
Discovery of antibiotics acting against Gram-negative species is uniquely challenging due to
their restrictive penetration barrier. BamA, which inserts proteins into the outer membrane, is …

Catheter-associated urinary tract infections: current challenges and future prospects

GT Werneburg - Research and reports in urology, 2022 - Taylor & Francis
Catheter-associated urinary tract infection (CAUTI) is the most common healthcare-
associated infection and cause of secondary bloodstream infections. Despite many …

[HTML][HTML] Phage therapy: a renewed approach to combat antibiotic-resistant bacteria

KE Kortright, BK Chan, JL Koff, PE Turner - Cell host & microbe, 2019 - cell.com
Phage therapy, long overshadowed by chemical antibiotics, is garnering renewed interest in
Western medicine. This stems from the rise in frequency of multi-drug-resistant bacterial …

Mining genomes to illuminate the specialized chemistry of life

MH Medema, T de Rond, BS Moore - Nature Reviews Genetics, 2021 - nature.com
All organisms produce specialized organic molecules, ranging from small volatile chemicals
to large gene-encoded peptides, that have evolved to provide them with diverse cellular and …

Resistance of gram-positive bacteria to current antibacterial agents and overcoming approaches

B Jubeh, Z Breijyeh, R Karaman - Molecules, 2020 - mdpi.com
The discovery of antibiotics has created a turning point in medical interventions to
pathogenic infections, but unfortunately, each discovery was consistently followed by the …

The antibiotic resistome: a guide for the discovery of natural products as antimicrobial agents

C Hobson, AN Chan, GD Wright - Chemical Reviews, 2021 - ACS Publications
The use of life-saving antibiotics has long been plagued by the ability of pathogenic bacteria
to acquire and develop an array of antibiotic resistance mechanisms. The sum of these …