Cancer stem cells (CSCs) represent a rare population of cells with the capacity to self-renew
and give rise to heterogeneous cell lineages within a tumour. Whilst the mechanisms …

Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm driven by BCR-
ABL1 oncoprotein, which plays a pivotal role in CML pathology, diagnosis, and treatment as …

The past decade has seen significant advances in our understanding of Hedgehog (HH)
signaling pathway in various biological events. HH signaling pathway exerts its biological …

Abstract Background Recently, circular RNAs (circRNAs) have been reported to be
microRNA sponges and play essential roles in cancer development. This study aimed to …

Cancer stem cells (CSCs) are a small subpopulation of tumor cells that have been identified
in most types of cancer. Features that distinguish them from the bulk of tumor cells include …

The conventional first-line chemotherapy for metastatic colorectal cancer (mCRC) consists of
fluorouracil (5-FU) in combination with either oxaliplatin or irinotecan. We have explored …

Cancer is a type of malignant affliction threatening human health worldwide; however, the
molecular mechanism of cancer pathogenesis remains to be elusive. The oncogenic …

Increasing evidence sustains that the establishment and maintenance of many, if not all,
human cancers are due to cancer stem cells (CSCs), tumor cells with stem cell properties …

Various signaling pathways exert critical roles in the epithelial to mesenchymal transition
(EMT) and cancer stem cells (CSCs). The Wnt/beta-catenin, PI3K/PTEN/Akt/mTORC …

Carnitine palmitoyl transferase 1A (CPT1A) protein catalyzes the rate-limiting step of Fatty-
acid oxidation (FAO) pathway, which can promote cell proliferation and suppress apoptosis …