Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease
There are several interrelated mechanisms involving iron, dopamine, and neuromelanin in
neurons. Neuromelanin accumulates during aging and is the catecholamine-derived …
neurons. Neuromelanin accumulates during aging and is the catecholamine-derived …
Protein design: toward functional metalloenzymes
F Yu, VM Cangelosi, ML Zastrow, M Tegoni… - Chemical …, 2014 - ACS Publications
Protein design is a valuable tool for understanding the fundamental factors that dictate
protein structure and function. The field of protein design has seen significant progress over …
protein structure and function. The field of protein design has seen significant progress over …
[HTML][HTML] Ribonucleotide reductases: essential enzymes for bacterial life
E Torrents - Frontiers in cellular and infection microbiology, 2014 - frontiersin.org
Ribonucleotide reductase (RNR) is a key enzyme that mediates the synthesis of
deoxyribonucleotides, the DNA precursors, for DNA synthesis in every living cell. This …
deoxyribonucleotides, the DNA precursors, for DNA synthesis in every living cell. This …
[HTML][HTML] Computational modelling of oxygenation processes in enzymes and biomimetic model complexes
SP de Visser, MG Quesne, B Martin… - Chemical …, 2014 - pubs.rsc.org
With computational resources becoming more efficient and more powerful and at the same
time cheaper, computational methods have become more and more popular for studies on …
time cheaper, computational methods have become more and more popular for studies on …
Copper reductase activity and free radical chemistry by cataract-associated human lens γ-crystallins
G Palomino-Vizcaino, N Schuth… - Journal of the …, 2023 - ACS Publications
Cataracts are caused by high-molecular-weight aggregates of human eye lens proteins that
scatter light, causing lens opacity. Metal ions have emerged as important potential players in …
scatter light, causing lens opacity. Metal ions have emerged as important potential players in …
Mechanism of assembly of the dimanganese-tyrosyl radical cofactor of class Ib ribonucleotide reductase: enzymatic generation of superoxide is required for tyrosine …
Ribonucleotide reductases (RNRs) utilize radical chemistry to reduce nucleotides to
deoxynucleotides in all organisms. In the class Ia and Ib RNRs, this reaction requires a …
deoxynucleotides in all organisms. In the class Ia and Ib RNRs, this reaction requires a …
New iminodiacetate–thiosemicarbazone hybrids and their copper (II) complexes are potential ribonucleotide reductase R2 inhibitors with high antiproliferative activity
MF Zaltariov, M Hammerstad, HJ Arabshahi… - Inorganic …, 2017 - ACS Publications
As ribonucleotide reductase (RNR) plays a crucial role in nucleic acid metabolism, it is an
important target for anticancer therapy. The thiosemicarbazone Triapine is an efficient R2 …
important target for anticancer therapy. The thiosemicarbazone Triapine is an efficient R2 …
Experimental and Computational X-ray Emission Spectroscopy as a Direct Probe of Protonation States in Oxo-Bridged MnIV Dimers Relevant to Redox-Active …
The protonation state of oxo bridges in nature is of profound importance for a variety of
enzymes, including the Mn4CaO5 cluster of photosystem II and the Mn2O2 cluster in Mn …
enzymes, including the Mn4CaO5 cluster of photosystem II and the Mn2O2 cluster in Mn …
Direct observation of structurally encoded metal discrimination and ether bond formation in a heterodinuclear metalloprotein
Although metallocofactors are ubiquitous in enzyme catalysis, how metal binding specificity
arises remains poorly understood, especially in the case of metals with similar primary …
arises remains poorly understood, especially in the case of metals with similar primary …
[HTML][HTML] Involvement of high-valent manganese-oxo intermediates in oxidation reactions: realisation in nature, nano and molecular systems
Manganese plays multiple role in many biological redox reactions in which it exists in
different oxidation states from Mn (II) to Mn (IV). Among them the high-valent manganese …
different oxidation states from Mn (II) to Mn (IV). Among them the high-valent manganese …