Unravelling the functional operation of neuronal networks and linking cellular activity to
specific behavioural outcomes are among the biggest challenges in neuroscience. In this …

Movement is accomplished by the controlled activation of motor unit populations. Our
understanding of motor unit physiology has been derived from experimental work on the …

Amyotrophic lateral sclerosis (ALS) is a devastating and fatal neurodegenerative disease of
adults which preferentially attacks the neuromotor system. Riluzole has been used as the …

At the beginning of the 20th century, Thomas Graham Brown conducted experiments that
after a long hiatus changed views on the neural control of locomotion. His seminal work …

The initiation and coordination of activity in limb muscles are the main functions of neural
circuits that control locomotion. Commissural neurons connect locomotor circuits on the two …

The organization of neural circuits that form the locomotor central pattern generator (CPG)
and provide flexor–extensor and left–right coordination of neuronal activity remains largely …

Many animals are capable of changing gait with speed of locomotion. The neural basis of
gait control and its dependence on speed are not fully understood. Mice normally use a …

Key points Quadrupeds express different gaits depending on speed of locomotion. Central
pattern generators (one per limb) within the spinal cord generate locomotor oscillations and …

Key points• The organization of the spinal circuitry responsible for the generation of
locomotor rhythm and control of locomotion in mammals is largely unknown, though several …

The basic pattern of rhythmic jaw movements produced during mastication is generated by a
neuronal network located in the brainstem and referred to as the masticatory central pattern …