[HTML][HTML] Cellular factors involved in the hepatitis C virus life cycle

HC Li, CH Yang, SY Lo - World Journal of Gastroenterology, 2021 - ncbi.nlm.nih.gov
The hepatitis C virus (HCV), an obligatory intracellular pathogen, highly depends on its host
cells to propagate successfully. The HCV life cycle can be simply divided into several stages …

Ubiquitination of UVRAG by SMURF1 promotes autophagosome maturation and inhibits hepatocellular carcinoma growth

X Feng, Y Jia, Y Zhang, F Ma, Y Zhu, X Hong, Q Zhou… - Autophagy, 2019 - Taylor & Francis
ABSTRACT UVRAG (UV radiation resistance associated) is an important regulator of
mammalian macroautophagy/autophagy by interacting with BECN1, PIK3C3, and RUBCN …

Susceptibilities of genotype 1a, 1b, and 3 hepatitis C virus variants to the NS5A inhibitor elbasvir

R Liu, S Curry, P McMonagle, WW Yeh… - Antimicrobial agents …, 2015 - Am Soc Microbiol
Elbasvir is an investigational NS5A inhibitor with in vitro activity against multiple HCV
genotypes. Antiviral activity of elbasvir was measured in replicons derived from wild-type or …

ASPP2 binds to hepatitis C virus NS5A protein via an SH3 domain/PxxP motif-mediated interaction and potentiates infection

A Smirnov, A Magri, R Lotz, X Han… - Journal of General …, 2023 - microbiologyresearch.org
Hepatitis C virus (HCV) infects millions of people worldwide and is a leading cause of liver
disease. Despite recent advances in antiviral therapies, viral resistance can limit drug …

SPSB2 inhibits hepatitis C virus replication by targeting NS5A for ubiquitination and degradation

M Wang, Y Wang, Y Liu, H Wang, X Xin, J Li, Y Hao… - Plos one, 2019 - journals.plos.org
Hepatitis C virus (HCV) replication involves many viral and host factors. Host factor SPRY
domain-and SOCS box-containing protein 2 (SPSB2) belongs to SPSB family, and it recruits …

Myxovirus resistance protein A inhibits hepatitis C virus replication through JAK-STAT pathway activation

H Wang, X Xin, M Wang, L Han, J Li, Y Hao, C Zheng… - Archives of …, 2018 - Springer
The interferon-inducible dynamin-like GTPase myxovirus resistance protein A (MxA) exhibits
activity against multiple viruses. However, its role in the life cycle of hepatitis C virus (HCV) is …

[PDF][PDF] Identification of the eEF1A2 expression level by RNA-seq analysis in doxorubicin-tolerant K562 cell lines

X Zhang, L Zou, D Yu, T Zhang, W Yao… - … OF CLINICAL AND …, 2016 - e-century.us
Myeloid neoplasms are broadly divided into acute myeloid leukemia (AML) and chronic
myeloid disorders. Understanding the molecular mechanisms of myeloid neoplasms is …

Hepatitis c virus nonstructural protein 5A: host cell protein-protein interactions and characterization of phosphorylated residues

T Chestley - 2017 - mspace.lib.umanitoba.ca
Hepatitis C virus (HCV) is a hepatotropic pathogen present in approximately 2.8% of the
population with 3-4 million new infections every year. Up to 85% of infections progress to a …