Mechanisms of resistance to CDK4/6 inhibitors: potential implications and biomarkers for clinical practice
A McCartney, I Migliaccio, M Bonechi, C Biagioni… - Frontiers in …, 2019 - frontiersin.org
The recent arrival of CDK4/6 inhibitor agents, with an approximate doubling of progression-
free survival (PFS) associated with their use in hormone receptor-positive, HER2-negative …
free survival (PFS) associated with their use in hormone receptor-positive, HER2-negative …
Longitudinal single-cell profiling reveals molecular heterogeneity and tumor-immune evolution in refractory mantle cell lymphoma
The mechanisms driving therapeutic resistance and poor outcomes of mantle cell lymphoma
(MCL) are incompletely understood. We characterize the cellular and molecular …
(MCL) are incompletely understood. We characterize the cellular and molecular …
CD44/CD133-positive colorectal cancer stem cells are sensitive to trifluridine exposure
Cancer stem cells (CSCs) are involved in metastatic colorectal cancer recurrence, but no
effective therapy targeting these cells is currently available. Because trifluridine …
effective therapy targeting these cells is currently available. Because trifluridine …
Loss of thymidine kinase 1 inhibits lung cancer growth and metastatic attributes by reducing GDF15 expression
P Malvi, R Janostiak, A Nagarajan, G Cai… - PLoS …, 2019 - journals.plos.org
Metabolic alterations that are critical for cancer cell growth and metastasis are one of the key
hallmarks of cancer. Here, we show that thymidine kinase 1 (TK1) is significantly …
hallmarks of cancer. Here, we show that thymidine kinase 1 (TK1) is significantly …
Application Value of Serum TK1 and PCDGF, CYFRA21‐1, NSE, and CEA plus Enhanced CT Scan in the Diagnosis of Nonsmall Cell Lung Cancer and …
X He, M Wang - Journal of oncology, 2022 - Wiley Online Library
Objective. To assess the application value of serum thymidine kinase 1 (TK1) and PC cell‐
derived growth factor (PCDGF), cytokeratin 19 fragment 21‐1 (CYFRA21‐1), neuron …
derived growth factor (PCDGF), cytokeratin 19 fragment 21‐1 (CYFRA21‐1), neuron …
Expression of Soluble Form of Aurora A as a Predictive Factor for Neoadjuvant Therapy in Breast Cancer Patients: A Single-Center Pilot Study
P Winter, M Fuksiewicz, A Jagiello-Gruszfeld… - Cancers, 2023 - mdpi.com
Simple Summary AURKA tissue expression has been shown to be a predictive and
prognostic factor in many solid tumors, including breast cancer. To improve the outcome of …
prognostic factor in many solid tumors, including breast cancer. To improve the outcome of …
Neural stem cells improve the delivery of oncolytic chimeric orthopoxvirus in a metastatic ovarian cancer model
M Hammad, YR Cornejo, J Batalla-Covello… - Molecular Therapy …, 2020 - cell.com
Oncolytic virotherapy represents a promising approach for treating recurrent and/or drug-
resistant ovarian cancer. However, its successful application in the clinic has been …
resistant ovarian cancer. However, its successful application in the clinic has been …
Photothermal mediated rolling circle amplification toward specific and direct in situ mRNA detection
D Liu, W Li, M Yang, L Qiu, H Pian, Y Huang… - Biosensors and …, 2021 - Elsevier
Rolling circle amplification (RCA) had the prospect of assisting clinic diagnosis with
advantage in in situ mRNA detection at single cell level. However, for direct mRNA …
advantage in in situ mRNA detection at single cell level. However, for direct mRNA …
[HTML][HTML] Clinical significance and role of TK1, CEA, CA 19-9 and CA 72-4 levels in diagnosis of colorectal cancers
S Singh, R Kumar, U Kumar… - Asian Pacific Journal of …, 2020 - ncbi.nlm.nih.gov
To explore the diagnostic value, pre-operative serum thymidine kinase 1 (TK1), CEA, CA 19-
9 and CA 72-4 levels were measured in 106 patients with colorectal carcinoma (53 colon …
9 and CA 72-4 levels were measured in 106 patients with colorectal carcinoma (53 colon …