Uric acid is the end product of purine metabolism in humans. Hyperuricemia is a metabolic
disease caused by the increased formation or reduced excretion of serum uric acid (SUA) …

Gut dysbiosis is suggested to play a critical role in the pathogenesis of gout. The aim of our
study was to identify the characteristic dysbiosis of the gut microbiota in gout patients and …

The increasing incidence of gout poses a very challenging management problem. However,
the currently available drugs often have various toxic side effects. As a traditional edible and …

Uric acid (UA) levels in blood serum have been associated with hypertension, indicating a
potential causal relationship between high serum UA levels and the progression of …

Xanthine dehydrogenase (XDH), a rate-limiting enzyme involved in purine metabolism, has
an essential role in inflammatory cascades. Researchers have known for decades that XDH …

Xanthine oxidase (XO) is a flavoprotein that exists in various organisms and can catalyze the
uric acid formation in the human body. Based on the amide framework of N-(4-((3 …

Pathologic calcification of cartilage consists of the formation of basic calcium phosphate
(BCP) and/or calcium pyrophosphate dihydrate (CPPD) containing calcium crystals in …

BackgroundWe aimed at exploring potential pathophysiological processes across psychotic
disorders, applying metabolomics in a large and well-characterized sample of patients and …

In recent years, biofilms have become a central subject of research in the fields of
microbiology, medicine, agriculture, and systems biology, among others. The …

Oxidative stress could be a possible mechanism and a therapeutic target of atrial fibrillation
(AF). However, the effects of the xanthine oxidase (XO) inhibition for AF remain to be fully …