Emerging biomarkers, tools, and treatments for diabetic polyneuropathy

GJ Bönhof, C Herder, A Strom, N Papanas… - Endocrine …, 2019 - academic.oup.com
Diabetic neuropathy, with its major clinical sequels, notably neuropathic pain, foot ulcers,
and autonomic dysfunction, is associated with substantial morbidity, increased risk of …

PTEN inhibition in human disease therapy

R Pulido - Molecules, 2018 - mdpi.com
The tumor suppressor PTEN is a major homeostatic regulator, by virtue of its lipid
phosphatase activity against phosphatidylinositol 3, 4, 5-trisphosphate [PI (3, 4, 5) P3], which …

Corneal neurotization for neurotrophic keratopathy: Review of surgical techniques and outcomes

CY Liu, AC Arteaga, SE Fung, MS Cortina… - The ocular …, 2021 - Elsevier
Neurotrophic keratopathy is a degenerative disease in which damage to the corneal nerves
leads to corneal hypoesthesia. Injuries to neurotrophic corneas are notoriously difficult to …

Unleashing intrinsic growth pathways in regenerating peripheral neurons

T Poitras, DW Zochodne - International Journal of Molecular Sciences, 2022 - mdpi.com
Common mechanisms of peripheral axon regeneration are recruited following diverse forms
of damage to peripheral nerve axons. Whether the injury is traumatic or disease related …

O-GlcNAcylation is crucial for sympathetic neuron development, maintenance, functionality and contributes to peripheral neuropathy

HF Wu, CW Huang, J Art, HX Liu, GW Hart… - Frontiers in …, 2023 - frontiersin.org
O-GlcNAcylation is a post-translational modification (PTM) that regulates a wide range of
cellular functions and has been associated with multiple metabolic diseases in various …

Aerobic exercise training may improve nerve function in type 2 diabetes and pre‐diabetes: A systematic review

Y Gu, SM Dennis, MC Kiernan… - … research and reviews, 2019 - Wiley Online Library
Diabetic neuropathy is a major complication of type 2 diabetes. Emerging evidence also
suggests that people with pre‐diabetes may develop similar symptoms related to nerve …

Engineering a platform for nerve regeneration with direct application to nerve repair technology

KM Pawelec, C Yoon, RJ Giger, J Sakamoto - Biomaterials, 2019 - Elsevier
The development of effective treatment options for repair of peripheral nerves is complicated
by lack of knowledge concerning the interactions between cells and implants. A promising …

Naringenin, a dietary flavanone, enhances insulin-like growth factor 1 receptor-mediated antioxidant defense and attenuates methylglyoxal-induced neurite damage …

YT Tseng, HT Hsu, TY Lee, WH Chang… - Nutritional …, 2021 - Taylor & Francis
Objectives: Recent studies revealed the neuroprotective effects of naringenin (NGEN), a
common dietary bioflavonoid contained in citrus fruits. However, there are limited data on its …

Peptide RL‐QN15 promotes regeneration of epidermal nerve fibers and recovery of sensory function in diabetic skin wounds

Y Wu, Y Wang, Z Fu, H Sun, Y Liu, C Li… - The FASEB …, 2023 - Wiley Online Library
Epidermal nerve fiber regeneration and sensory function are severely impaired in skin
wounds of diabetic patients. To date, however, research on post‐traumatic nerve …

Failure to upregulate the RNA binding protein ZBP after injury leads to impaired regeneration in a rodent model of diabetic peripheral neuropathy

JI Jones, CJ Costa, C Cooney, DC Goldberg… - Frontiers in Molecular …, 2021 - frontiersin.org
Most diabetes patients eventually suffer from peripheral nerve degeneration. Unfortunately,
there is no treatment for the condition and its mechanisms are not well understood. There is …