Amphiphilic copolymers consisting of alternating hydrophilic and hydrophobic units account
for a major recent methodical breakthrough in the investigations of membrane proteins …

Compared to soluble protein counterparts, the understanding of membrane protein stability,
solvent interactions, and function are not as well understood. Recent advancements in …

Amphipathic copolymers such as poly (styrene-maleic acid)(SMA) are promising tools for the
facile extraction of membrane proteins (MPs) into native nanodiscs. Here, we designed and …

Discoidal lipid-protein nanoparticles known as nanodiscs are widely used tools in structural
and membrane biology. Amphipathic, synthetic copolymers have recently become an …

Even though the cell wall has been recognized as a crucial protective organelle for fungi,
essential for its virulence and a unique emblem of this kingdom, biosynthesis of this …

Membrane recognition by viral spike proteins is critical for infection. Here we show the host
cell membrane-binding surfaces of severe acute respiratory syndrome coronavirus 2 (SARS …

Introduction The proteins that decipher nucleic acid-and protein-based information are well
known, however, those that read membrane-encoded information remain understudied …

The detergent-free isolation of membrane proteins using synthetic polymers is becoming the
desired approach for functional and structural studies of membrane proteins. Since the …

Structures can now be predicted for any protein using programs like AlphaFold and Rosetta,
which rely on a foundation of experimentally determined structures of architecturally diverse …

Extraction of membrane proteins from biological membranes has traditionally involved
detergents. In the past decade, a new technique has been developed, which uses styrene …