Itch is a common sensory experience that is prevalent in patients with inflammatory skin
diseases, as well as in those with systemic and neuropathic conditions. In patients with …

For centuries, itch was categorized as a submodality of pain. Recent research over the last
decade has led to the realization that itch is in fact a separate and distinct, albeit closely …

Key Clinical Points Chronic Pruritus Chronic pruritus (itching that persists for more than 6
weeks) may be caused by inflammatory skin diseases, systemic diseases, neuropathic …

Itch pathogenesis is broadly characterized into histaminergic and nonhistaminergic
pathways and transmitted via 2 main receptor families: G protein–coupled receptors and …

Itch is described as an irritating sensation that triggers a desire to scratch. However, this
definition hardly seems fitting for the millions of people who suffer from intractable itch …

Itch, in particular chronic forms, has been widely recognized as an important clinical
problem, but much less is known about the mechanisms of itch in comparison with other …

Chronic itch is associated with increased stress, anxiety, and other mood disorders. In turn,
stress and anxiety exacerbate itch, leading to a vicious cycle that affects patient behavior …

Pruritus, also known as itch, is a very common, unpleasant sensation that elicits an urge to
scratch. Its origin is not always in the skin, and neuropathic itch that is caused by neuronal or …

The itch-scratch reflex serves as a protective mechanism in everyday life. However, chronic
persistent itching can be devastating. Despite the clinical importance of the itch sensation, its …

Acute itch can be generated by either chemical or mechanical stimuli, which activate
separate pathways in the periphery and spinal cord. While substantial progress has been …