Inflammatory and immunometabolic consequences of gut dysfunction in HIV: parallels with IBD and implications for reservoir persistence and non-AIDS comorbidities
The gastrointestinal mucosa is critical for maintaining the integrity and functions of the gut.
Disruption of this barrier is a hallmark and a risk factor for many intestinal and chronic …
Disruption of this barrier is a hallmark and a risk factor for many intestinal and chronic …
The Th17 lineage: from barrier surfaces homeostasis to autoimmunity, cancer, and HIV-1 pathogenesis
The T helper 17 (Th17) cells represent a subset of CD4+ T-cells with unique effector
functions, developmental plasticity, and stem-cell features. Th17 cells bridge innate and …
functions, developmental plasticity, and stem-cell features. Th17 cells bridge innate and …
[HTML][HTML] Associations of body mass index at different ages with early-onset colorectal cancer
Background & Aims Incidence of colorectal cancer (CRC) in younger adults is increasing in
many countries. Given the established association of body mass index (BMI) with CRC risk …
many countries. Given the established association of body mass index (BMI) with CRC risk …
Anti-apoptotic protein BIRC5 maintains survival of HIV-1-infected CD4+ T cells
Summary HIV-1 infection of CD4+ T cells leads to cytopathic effects and cell demise, which
is counter to the observation that certain HIV-1-infected cells possess a remarkable long …
is counter to the observation that certain HIV-1-infected cells possess a remarkable long …
Butyrate directly decreases human gut lamina propria CD4 T cell function through histone deacetylase (HDAC) inhibition and GPR43 signaling
JJ Kibbie, SM Dillon, TA Thompson, CM Purba… - Immunobiology, 2021 - Elsevier
An important function of the gut microbiome is the fermentation of non-digestible dietary
fibers into short chain fatty acids (SCFAs). The three primary SCFAs: acetate, propionate …
fibers into short chain fatty acids (SCFAs). The three primary SCFAs: acetate, propionate …
Integrative systems immunology uncovers molecular networks of the cell cycle that stratify COVID‐19 severity
CAS Prado, DLM Fonseca, Y Singh… - Journal of Medical …, 2023 - Wiley Online Library
Several perturbations in the number of peripheral blood leukocytes, such as neutrophilia
and lymphopenia associated with Coronavirus disease 2019 (COVID‐19) severity, point to …
and lymphopenia associated with Coronavirus disease 2019 (COVID‐19) severity, point to …
Relationship between human immunodeficiency virus (HIV-1) infection and chronic periodontitis
TLS Pólvora, ÁVV Nobre, C Tirapelli… - Expert review of …, 2018 - Taylor & Francis
Introduction: Current studies show that, even in the era of antiretroviral therapies, HIV-1
infection is associated with more severe and frequent refractory chronic periodontitis. Areas …
infection is associated with more severe and frequent refractory chronic periodontitis. Areas …
New Th17-specific therapeutic strategies for HIV remission
New Th17-specific therapeutic strategies for HIV remission : Current Opinion in HIV and AIDS
New Th17-specific therapeutic strategies for HIV remission : Current Opinion in HIV and AIDS …
New Th17-specific therapeutic strategies for HIV remission : Current Opinion in HIV and AIDS …
Influence of gut microbiome on mucosal immune activation and SHIV viral transmission in naive macaques
It is unknown whether the gut microbiome affects HIV transmission. In our recent SHIV
vaccine study, we found that the naive rhesus macaques from two different sources had …
vaccine study, we found that the naive rhesus macaques from two different sources had …
Qualitative differences between the IFNα subtypes and IFNβ influence chronic mucosal HIV-1 pathogenesis
The Type I Interferons (IFN-Is) are innate antiviral cytokines that include 12 different IFNα
subtypes and IFNβ that signal through the IFN-I receptor (IFNAR), inducing hundreds of IFN …
subtypes and IFNβ that signal through the IFN-I receptor (IFNAR), inducing hundreds of IFN …