Lipid‐lowering trials are not representative of patients managed in clinical practice: a systematic review and meta‐analysis of exclusion criteria

M Aeschbacher‐Germann, N Kaiser… - Journal of the …, 2023 - Am Heart Assoc
Background Randomized clinical trials (RCTs) might not be representative of the real‐world
population because of unreasonable exclusion criteria. We sought to determine which …

[HTML][HTML] PoLA/CFPiP/PCS/PSLD/PSD/PSH guidelines on diagnosis and therapy of lipid disorders in Poland 2021

M Banach, P Burchardt, K Chlebus… - Archives of Medical …, 2021 - ncbi.nlm.nih.gov
Moreover, over the last few years the approach to treatment of patients with a high
cardiovascular risk has totally changed from treatment aimed at a specific risk factor (ie …

Recommendations on deprescribing of bisphosphonates in osteoporosis guidelines: a systematic review

DB Jepsen, ES Bergen, J Pan, E van Poelgeest… - European Geriatric …, 2023 - Springer
Purpose Advancing age, declining health status, and a shift in benefit/risk balance warrant
judicious use of preventive medications in older persons, including consideration of …

Statin discontinuation and cardiovascular events among older people in Denmark

W Thompson, L Morin, DE Jarbøl… - JAMA network …, 2021 - jamanetwork.com
Importance Statin use is common in older persons. Given uncertainties in ongoing benefit,
changes in health status, and shifting goals of care and preferences, statin discontinuation …

Statins, mortality, and major adverse cardiovascular events among US veterans with chronic kidney disease

O Barayev, CE Hawley, H Wellman… - JAMA Network …, 2023 - jamanetwork.com
Importance There are limited data for the utility of statins for primary prevention of
atherosclerotic cardiovascular disease (ASCVD) and death in adults with chronic kidney …

New statin use, mortality, and first cardiovascular events in older US Veterans by frailty status

AR Orkaby, B Lu, YL Ho, T Treu… - Journal of the …, 2024 - Wiley Online Library
Background Statins are part of long‐term medical regimens for many older adults. Whether
frailty modifies the protective relationship between statins, mortality, and major adverse …

Classical risk factors for primary coronary artery disease from an aging perspective through Mendelian Randomization

SA Jansen, B Huiskens, S Trompet, JW Jukema… - Geroscience, 2022 - Springer
The significance of classical risk factors in coronary artery disease (CAD) remains unclear in
older age due to possible changes in underlying disease pathologies. Therefore, we …

Discontinuation of statins in veterans admitted to nursing homes near the end of life

CT Thorpe, FE Sileanu, MK Mor, X Zhao… - Journal of the …, 2020 - Wiley Online Library
BACKGROUND/OBJECTIVES Geriatric guidelines recommend against statin use in older
adults with limited life expectancy (LLE) or advanced dementia (AD). This study examined …

Primary prevention statin therapy in older adults

MG Nanna, A Abdullah, MB Mortensen… - Current opinion in …, 2023 - journals.lww.com
Primary prevention statin therapy in older adults : Current Opinion in Cardiology Primary
prevention statin therapy in older adults : Current Opinion in Cardiology Log in or Register …

Sex and stroke risk factors: A review of differences and impact

M Hanna, A Wabnitz, P Grewal - Journal of Stroke and Cerebrovascular …, 2024 - Elsevier
Objectives There is an increase in stroke incidence risk over the lifetime of women, given
their longer life expectancy. However, an alarming trend for sex disparities, particularly in …