Osteoimmunology: evolving concepts in bone–immune interactions in health and disease

M Tsukasaki, H Takayanagi - Nature Reviews Immunology, 2019 - nature.com
In terrestrial vertebrates, bone tissue constitutes the 'osteoimmune'system, which functions
as a locomotor organ and a mineral reservoir as well as a primary lymphoid organ where …

Osteonecrosis of the jaw and antiresorptive agents in benign and malignant diseases: a critical review organized by the ECTS

AD Anastasilakis, J Pepe, N Napoli… - The Journal of …, 2022 - academic.oup.com
Context Antiresorptive therapy significantly reduces fracture risk in patients with benign bone
disease and skeletal-related events (SREs) in patients with bone metastases (BM) …

Infection as an important factor in medication-related osteonecrosis of the jaw (MRONJ)

S Otto, S Aljohani, R Fliefel, S Ecke, O Ristow, E Burian… - Medicina, 2021 - mdpi.com
Medication-related osteonecrosis of the jaw (MRONJ) has become a well-known side effect
of antiresorptive, and antiangiogenic drugs commonly used in cancer management. Despite …

Relationship between tooth extraction and development of medication-related osteonecrosis of the jaw in cancer patients

S Soutome, M Otsuru, S Hayashida, M Murata… - Scientific Reports, 2021 - nature.com
Tooth extraction has been avoided since it has been considered a major risk factor for
medication-related osteonecrosis of the jaw (MRONJ). However, MRONJ may also develop …

Incidence and risk factors for medication‐related osteonecrosis after tooth extraction in cancer patients—A systematic review

N Schwech, J Nilsson, P Gabre - Clinical and Experimental …, 2023 - Wiley Online Library
Objectives Antiresorptive medication has been reported to be associated with medication‐
related osteonecrosis of the jaw (MRONJ). This systematic review aims at investigating the …

The role of the immune response in the development of medication-related osteonecrosis of the jaw

W Zhang, L Gao, W Ren, S Li, J Zheng, S Li… - Frontiers in …, 2021 - frontiersin.org
Medication-related osteonecrosis of the jaw (MRONJ) is a rare but serious adverse drug
effect. There are multiple hypotheses to explain the development of MRONJ. Reduced bone …

Medication-related osteonecrosis of the jaw after tooth extraction in cancer patients: a multicenter retrospective study

T Hasegawa, S Hayashida, E Kondo, Y Takeda… - Osteoporosis …, 2019 - Springer
Root amputation, immunosuppressive therapy, mandibular tooth extraction, pre-existing
inflammation, and longer duration of treatment with bone-modifying agents were significantly …

Alveolar bone histological necrosis observed prior to extractions in patients, who received bone‐targeting agents

O Nicolatou‐Galitis, E Papadopoulou, E Vardas… - Oral …, 2020 - Wiley Online Library
Objective We reported the alveolar bone histology prior to dental extractions in cancer
patients, who received bone‐targeting agents (BTA). Subjects and Methods Fifty‐four …

Denosumab-related osteonecrosis of the jaw after tooth extraction and the effects of a short drug holiday in cancer patients: a multicenter retrospective study

T Hasegawa, N Ueda, SI Yamada, S Kato… - Osteoporosis …, 2021 - Springer
Pre-existing inflammation, corticosteroid therapy, periapical periodontitis, longer duration of
denosumab therapy, and female sex were significantly associated with an increased risk of …

Wound closure and alveoplasty after preventive tooth extractions in patients with antiresorptive intake—A randomized pilot trial

O Ristow, T Rückschloß, J Moratin, M Müller… - Oral …, 2021 - Wiley Online Library
Objectives To compare success rates between the sub‐periosteal prepared (SPP) muco‐
periosteal flap and the epi‐periosteal prepared (EPP) mucosa flap and the feasibility of …