Abstract Interleukin-6 (IL-6) is a key immunomodulatory cytokine that affects the
pathogenesis of diverse diseases, including autoimmune diseases, chronic inflammatory …

The interleukin (IL)-6 family cytokines is a group of cytokines consisting of IL-6, IL-11, ciliary
neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM) …

IL-6 is a pleiotropic cytokine with broad-ranging effects within the integrated immune
response. One of the roles of IL-6 is to support immunocompetence, defined as the ability of …

The disintegrin metalloprotease ADAM17 has been a matter of intense studies aiming to
unravel structure, function and regulation of protease expression, maturation and activity. In …

Regulated cell death is a major mechanism to eliminate damaged, infected, or superfluous
cells. Previously, apoptosis was thought to be the only regulated cell death mechanism; …

Abstract Interleukin-6 (IL-6) is a cytokine, which is involved in innate and acquired immunity,
in neural cell maintenance and in metabolism. IL-6 can be synthesized by many different …

Interleukin (IL)‐6 binds to IL‐6R and the complex of IL‐6 and IL‐6R associates with the
receptor subunit gp130, which initiates signaling. gp130 is expressed on all cells. IL‐6R is …

Rationale Premature infants exposed to oxygen are at risk for bronchopulmonary dysplasia
(BPD), which is characterised by lung growth arrest. Inflammation is important, but the …

All ligands of the epidermal growth factor receptor (EGF-R) are transmembrane proteins,
which need to be proteolytically cleaved in order to be systemically active. The major …

Lung cancer is the leading cause of cancer-related mortality, which histologically is
classified into small-cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) …