Progress in Metabolic Engineering of Saccharomyces cerevisiae

E Nevoigt - Microbiology and Molecular Biology Reviews, 2008 - Am Soc Microbiol
The traditional use of the yeast Saccharomyces cerevisiae in alcoholic fermentation has,
over time, resulted in substantial accumulated knowledge concerning genetics, physiology …

[HTML][HTML] Scaling up xylitol bioproduction: Challenges to achieve a profitable bioprocess

SS Queiroz, FM Jofre, SI Mussatto… - … and Sustainable Energy …, 2022 - Elsevier
Xylitol is a GRAS (Generally Recognized as Safe) polyol commonly used in the food industry
and able to promote several benefits to the health. In addition, it can also be used as a …

Adaptations in metabolism and protein translation give rise to the Crabtree effect in yeast

C Malina, R Yu, J Björkeroth… - Proceedings of the …, 2021 - National Acad Sciences
Aerobic fermentation, also referred to as the Crabtree effect in yeast, is a well-studied
phenomenon that allows many eukaryal cells to attain higher growth rates at high glucose …

Improving recombinant protein production by yeast through genome-scale modeling using proteome constraints

F Li, Y Chen, Q Qi, Y Wang, L Yuan, M Huang… - Nature …, 2022 - nature.com
Eukaryotic cells are used as cell factories to produce and secrete multitudes of recombinant
pharmaceutical proteins, including several of the current top-selling drugs. Due to the …

Resource competition and social conflict in experimental populations of yeast

RC MacLean, I Gudelj - Nature, 2006 - nature.com
Understanding the conditions that promote the maintenance of cooperation is a classic
problem in evolutionary biology,,,,. The essence of this dilemma is captured by the 'tragedy …

Rewiring yeast sugar transporter preference through modifying a conserved protein motif

EM Young, A Tong, H Bui… - Proceedings of the …, 2014 - National Acad Sciences
Utilization of exogenous sugars found in lignocellulosic biomass hydrolysates, such as
xylose, must be improved before yeast can serve as an efficient biofuel and biochemical …

Differential scaling between G1 protein production and cell size dynamics promotes commitment to the cell division cycle in budding yeast

A Litsios, DHEW Huberts, HM Terpstra, P Guerra… - Nature cell …, 2019 - nature.com
In the unicellular eukaryote Saccharomyces cerevisiae, Cln3–cyclin-dependent kinase
activity enables Start, the irreversible commitment to the cell division cycle. However, the …

Full humanization of the glycolytic pathway in Saccharomyces cerevisiae

FJ Boonekamp, E Knibbe, MA Vieira-Lara, M Wijsman… - Cell Reports, 2022 - cell.com
Although transplantation of single genes in yeast plays a key role in elucidating gene
functionality in metazoans, technical challenges hamper humanization of full pathways and …

A putative bet-hedging strategy buffers budding yeast against environmental instability

LE Bagamery, QA Justman, EC Garner, AW Murray - Current Biology, 2020 - cell.com
To grow and divide, cells must extract resources from dynamic and unpredictable
environments. Many organisms use different metabolic strategies for distinct contexts …

Intracellular characterization of aerobic glucose metabolism in seven yeast species by 13C flux analysis and metabolomics

S Christen, U Sauer - FEMS yeast research, 2011 - academic.oup.com
Key distinguishing characteristics of yeast glucose metabolism are the relative proportions of
fermentation and respiration. Crabtree-positive yeast species exhibit a respirofermentative …