Alzheimer's disease (AD) is a devastating age-related neurodegenerative disorder with an
alarming increasing prevalence. Except for the recently FDA-approved Aducanumab of …

The endotoxin hypothesis of neurodegeneration is the hypothesis that endotoxin causes or
contributes to neurodegeneration. Endotoxin is a lipopolysaccharide (LPS), constituting …

Porphyromonas gingivalis, the keystone pathogen in chronic periodontitis, was identified in
the brain of Alzheimer's disease patients. Toxic proteases from the bacterium called …

One of the most important scientific discoveries of recent years was the disclosure that the
intestinal microflora takes part in bidirectional communication between the gut and the brain …

Alzheimer's disease (AD), a common neurodegenerative disease in the elderly and the most
prevalent cause of dementia, is characterized by progressive cognitive impairment. The …

Background The results from cross sectional and longitudinal studies show that periodontitis
is closely associated with cognitive impairment (CI) and Alzhemer's Disease (AD). Further …

Background: Inflammation is a part of the first line of defense of the body against invasive
pathogens, and plays a crucial role in tissue regeneration and repair. A proper inflammatory …

Periodontitis is a chronic inflammatory disease of the gums. The incidence of periodontitis is
increasing all over the world. In patients with periodontitis, there is gradual destruction of the …

Background Although recent short-term cross-sectional studies have revealed that chronic
periodontitis (CP) may be a risk factor for increased cognitive impairment in patients with …

The evidence of a connection between the peripheral inflammatory processes and
neurodegenerative diseases of the central nervous system is becoming more apparent. This …