Current advancements in spinal cord Injury Research—glial scar formation and neural regeneration
Spinal cord injury (SCI) is a complex tissue injury resulting in permanent and degenerating
damage to the central nervous system (CNS). Detrimental cellular processes occur after SCI …
damage to the central nervous system (CNS). Detrimental cellular processes occur after SCI …
Cell transplantation therapy for spinal cord injury
Spinal cord injury can lead to severe motor, sensory and autonomic dysfunction. Currently,
there is no effective treatment for the injured spinal cord. The transplantation of Schwann …
there is no effective treatment for the injured spinal cord. The transplantation of Schwann …
Restorative effects of human neural stem cell grafts on the primate spinal cord
ES Rosenzweig, JH Brock, P Lu, H Kumamaru… - Nature medicine, 2018 - nature.com
We grafted human spinal cord–derived neural progenitor cells (NPCs) into sites of cervical
spinal cord injury in rhesus monkeys (Macaca mulatta). Under three-drug …
spinal cord injury in rhesus monkeys (Macaca mulatta). Under three-drug …
Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics
Epidural electrical stimulation (EES) of the spinal cord and real-time processing of gait
kinematics are powerful methods for the study of locomotion and the improvement of motor …
kinematics are powerful methods for the study of locomotion and the improvement of motor …
Chondroitinase improves anatomical and functional outcomes after primate spinal cord injury
ES Rosenzweig, EA Salegio, JJ Liang, JL Weber… - Nature …, 2019 - nature.com
Inhibitory extracellular matrices form around mature neurons as perineuronal nets
containing chondroitin sulfate proteoglycans that limit axonal sprouting after CNS injury. The …
containing chondroitin sulfate proteoglycans that limit axonal sprouting after CNS injury. The …
Efficacy of ultra-early (< 12 h), early (12–24 h), and late (> 24–138.5 h) surgery with magnetic resonance imaging-confirmed decompression in American Spinal Injury …
In cervical traumatic spinal cord injury (TSCI), the therapeutic effect of timing of surgery on
neurological recovery remains uncertain. Additionally, the relationship between extent of …
neurological recovery remains uncertain. Additionally, the relationship between extent of …
Extent of spinal cord decompression in motor complete (American Spinal Injury Association Impairment Scale Grades A and B) traumatic spinal cord injury patients …
Although decompressive surgery following traumatic spinal cord injury (TSCI) is
recommended, adequate surgical decompression is rarely verified via imaging. We utilized …
recommended, adequate surgical decompression is rarely verified via imaging. We utilized …
Efficacy of early (≤ 24 hours), Late (25–72 hours), and Delayed (> 72 hours) surgery with magnetic resonance imaging-confirmed decompression in American spinal …
B Aarabi, N Akhtar-Danesh, JM Simard… - Journal of …, 2021 - liebertpub.com
The therapeutic significance of timing of decompression in acute traumatic central cord
syndrome (ATCCS) caused by spinal stenosis remains unsettled. We retrospectively …
syndrome (ATCCS) caused by spinal stenosis remains unsettled. We retrospectively …
Pathophysiology of traumatic spinal cord injury
S Couillard-Despres, L Bieler, M Vogl - Neurological aspects of spinal …, 2017 - Springer
Traumatic spinal cord injury (SCI) is a drama in two acts. The first part represents the trauma
itself, causing the destruction of neural tissue, ie, the elimination of neuronal and glial cells …
itself, causing the destruction of neural tissue, ie, the elimination of neuronal and glial cells …
Targeting translational successes through CANSORT-SCI: using pet dogs to identify effective treatments for spinal cord injury
Translation of therapeutic interventions for spinal cord injury (SCI) from laboratory to clinic
has been historically challenging, highlighting the need for robust models of injury that more …
has been historically challenging, highlighting the need for robust models of injury that more …