Current advancements in spinal cord Injury Research—glial scar formation and neural regeneration

T Clifford, Z Finkel, B Rodriguez, A Joseph, L Cai - Cells, 2023 - mdpi.com
Spinal cord injury (SCI) is a complex tissue injury resulting in permanent and degenerating
damage to the central nervous system (CNS). Detrimental cellular processes occur after SCI …

Cell transplantation therapy for spinal cord injury

P Assinck, GJ Duncan, BJ Hilton, JR Plemel… - Nature …, 2017 - nature.com
Spinal cord injury can lead to severe motor, sensory and autonomic dysfunction. Currently,
there is no effective treatment for the injured spinal cord. The transplantation of Schwann …

Restorative effects of human neural stem cell grafts on the primate spinal cord

ES Rosenzweig, JH Brock, P Lu, H Kumamaru… - Nature medicine, 2018 - nature.com
We grafted human spinal cord–derived neural progenitor cells (NPCs) into sites of cervical
spinal cord injury in rhesus monkeys (Macaca mulatta). Under three-drug …

Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics

M Capogrosso, FB Wagner, J Gandar, EM Moraud… - Nature …, 2018 - nature.com
Epidural electrical stimulation (EES) of the spinal cord and real-time processing of gait
kinematics are powerful methods for the study of locomotion and the improvement of motor …

Chondroitinase improves anatomical and functional outcomes after primate spinal cord injury

ES Rosenzweig, EA Salegio, JJ Liang, JL Weber… - Nature …, 2019 - nature.com
Inhibitory extracellular matrices form around mature neurons as perineuronal nets
containing chondroitin sulfate proteoglycans that limit axonal sprouting after CNS injury. The …

Efficacy of ultra-early (< 12 h), early (12–24 h), and late (> 24–138.5 h) surgery with magnetic resonance imaging-confirmed decompression in American Spinal Injury …

B Aarabi, N Akhtar-Danesh, T Chryssikos… - Journal of …, 2020 - liebertpub.com
In cervical traumatic spinal cord injury (TSCI), the therapeutic effect of timing of surgery on
neurological recovery remains uncertain. Additionally, the relationship between extent of …

Extent of spinal cord decompression in motor complete (American Spinal Injury Association Impairment Scale Grades A and B) traumatic spinal cord injury patients …

B Aarabi, J Olexa, T Chryssikos, SM Galvagno… - Journal of …, 2019 - liebertpub.com
Although decompressive surgery following traumatic spinal cord injury (TSCI) is
recommended, adequate surgical decompression is rarely verified via imaging. We utilized …

Efficacy of early (≤ 24 hours), Late (25–72 hours), and Delayed (> 72 hours) surgery with magnetic resonance imaging-confirmed decompression in American spinal …

B Aarabi, N Akhtar-Danesh, JM Simard… - Journal of …, 2021 - liebertpub.com
The therapeutic significance of timing of decompression in acute traumatic central cord
syndrome (ATCCS) caused by spinal stenosis remains unsettled. We retrospectively …

Pathophysiology of traumatic spinal cord injury

S Couillard-Despres, L Bieler, M Vogl - Neurological aspects of spinal …, 2017 - Springer
Traumatic spinal cord injury (SCI) is a drama in two acts. The first part represents the trauma
itself, causing the destruction of neural tissue, ie, the elimination of neuronal and glial cells …

Targeting translational successes through CANSORT-SCI: using pet dogs to identify effective treatments for spinal cord injury

SA Moore, N Granger, NJ Olby, I Spitzbarth… - Journal of …, 2017 - liebertpub.com
Translation of therapeutic interventions for spinal cord injury (SCI) from laboratory to clinic
has been historically challenging, highlighting the need for robust models of injury that more …