Approximately 40% of treatments of chronic and recurrent osteomyelitis fail in part due to
bacterial persistence. Staphylococcus aureus, the predominant pathogen in human …

Daptomycin is a lipopeptide antibiotic produced by the soil bacterium Streptomyces
roseosporus that is clinically used to treat severe infections with Gram-positive bacteria. In …

Integration of two distinctive bactericides into one entity is a promising platform to improve
the efficiency of antimicrobial agents. We report an efficient antimicrobial hybrid formed …

An ideal antibiotic is an antibacterial agent that kills or inhibits the growth of all harmful
bacteria in a host, regardless of site of infection without affecting beneficial gut microbes (gut …

Patients with infective endocarditis (IE) form a heterogeneous group, ranging from those
who are successfully treated with no adverse events, to those with severe complications and …

Antimicrobial peptides (AMPs) are endogenous polypeptides produced by multicellular
organisms in order to protect a host from pathogenic microbes. AMPs are also defined as …

The increase in antibiotic resistance calls for accelerated molecular engineering strategies
to diversify natural products for drug discovery. The incorporation of non-canonical amino …

Brilacidin (PMX30063) has shown potent bactericidal activity against drug-resistant and-
susceptible strains of multiple Gram-negative and Gram-positive pathogens. In this study, we …

Peptides in general hold much promise as a major ingredient in novel supramolecular
assemblies. They may become essential in vaccine design, antimicrobial chemotherapy …

Vaccines and antibiotics have significantly contributed to improve health and also to
increase the longevity of human beings. The fast-acting effect of antibiotics makes them …