Background Beta-lactam antibiotics (βLA) are the most commonly used antibiotics in the
intensive care unit (ICU). ICU patients present many pathophysiological features that cause …

Antimicrobials are among the most important and commonly prescribed drugs in the
management of critically ill patients and beta-lactams are the most common antibiotic class …

Objective: To discuss the altered pharmacokinetic properties of selected antibiotics in
critically ill patients and to develop basic dose adjustment principles for this patient …

Background The rates of antibiotic resistance in Gram-negative bacteria are increasing. One
method to minimize resistance emergence may be optimization of antibiotic dosing …

Introduction Several reports have shown marked heterogeneity of antibiotic
pharmacokinetics (PK) in patients admitted to ICUs, which might potentially affect outcomes …

Pseudomonas aeruginosa and Acinetobacter baumannii are major nosocomial pathogens
worldwide. Both are intrinsically resistant to many drugs and are able to become resistant to …

The continued rise in infections caused by extended-spectrum β-lactamase (ESBL)–
producing pathogens is recognized globally as one of the most pressing concerns facing the …

Cefepime is a broad-spectrum fourth-generation cephalosporin with activity against Gram-
positive and Gram-negative pathogens. It is generally administered as an infusion over 30 …

Objective: The clinical benefits of extended infusion or continuous infusion of β-lactam
antibiotics remain controversial. We systematically reviewed the literature to determine …

Background. Extended-spectrum ß-lactamase (ESBL)–producing Enterobacteriaceae
isolates are important clinical pathogens. In addition, the efficacy of cefepime for such …