▪ Abstract The heparan sulfate on the surface of all adherent cells modulates the actions of a
large number of extracellular ligands. Members of both cell surface heparan sulfate …

Proteoglycans are a heterogeneous class of proteins bearing sulfated glycosaminoglycans.
Some of the proteoglycans have distinct core protein structures, and others display …

This review will summarize our current state of knowledge of the structure, biochemical
properties and functions of syndecans, a family of transmembrane heparan sulphate …

The syndecans are a gene family of four transmembrane heparan sulfate proteoglycans that
bind, via their HS chains, diverse components of the cellular microenvironment. To evaluate …

The domainal nature of proteins is well established. What is less certain is how many
domains are evolutionarily mobile in that they occur in otherwise nonhomologous proteins …

Proteoglycans control numerous normal and pathological processes, among which are
morphogenesis, tissue repair, inflammation, vascularization and cancer metastasis. During …

Mice lacking syndecan-1 are viable, fertile and have morphologically normal skin, hair and
ocular surface epithelia. While studying the response of these mice to corneal epithelial and …

Cell surface proteoglycans are known to be important regulators of many aspects of cell
behavior. The principal family of transmembrane proteoglycans is the syndecans, of which …

Most proteoglycans bear either chondroitin sulfate or heparan sulfate chains linked to serine
residues at Ser-Gly attachment sites on the core protein. However, only a fraction of proteins …

Two myeloma cell lines, MPC-11 and P3X63Ag8. 653 (P3), have almost identical amounts
of syndecan-1 at their cell surface. The syndecan-1 molecules from both lines are similar in …