Dengue is the most prevalent arthropod-borne viral disease worldwide and affects
approximately 2.5 billion people living in over 100 countries. Increasing geographic …

The non-structural protein 5 (NS5) of flaviviruses is the most conserved amongst the viral
proteins. It is about 900 kDa and bears enzymatic activities that play vital roles in virus …

The dengue virus and related flaviviruses are an increasing global health threat. In this
perspective, we comment on and review medicinal chemistry efforts aimed at the prevention …

West Nile virus (WNV) and Dengue virus (DENV) are important human pathogens for which
there are presently no vaccine or specific antivirals. We report herein a 5′-silylated …

Flavivirus methyltransferase (MTase) is essential for viral replication. Here we report the
identification of small molecules through virtual screening that putatively bind to the SAM …

Introduction: Flaviviruses are major causes of infectious disease. The vast global, social and
economic impact due to morbidity and mortality associated with diseases caused by these …

Flaviviruses are among the most critical pathogens in tropical regions and cause a growing
number of severe diseases in developing countries. The development of antiviral …

A unique feature of coronaviruses is their utilization of self-encoded nonstructural protein 16
(nsp16), 2′-O-methyltransferase (2′-O-MTase), to cap their RNAs through ribose 2′-O …

The positive-sense flavivirus RNA genome bears a cap 1 structure essential for RNA stability
and viral protein translation, and the formation of cap 1 requires the virally encoded …

Alongshan virus (ALSV), a newly discovered member of unclassified Flaviviridae family, is
able to infect humans. ALSV has a multi-segmented genome organization and is …