Metabolomics in cancer research and emerging applications in clinical oncology

DR Schmidt, R Patel, DG Kirsch… - CA: a cancer journal …, 2021 - Wiley Online Library
Cancer has myriad effects on metabolism that include both rewiring of intracellular
metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor …

Emerging applications of metabolomics in drug discovery and precision medicine

DS Wishart - Nature reviews Drug discovery, 2016 - nature.com
Metabolomics is an emerging'omics' science involving the comprehensive characterization
of metabolites and metabolism in biological systems. Recent advances in metabolomics …

[HTML][HTML] The crucial role of multiomic approach in cancer research and clinically relevant outcomes

M Lu, X Zhan - EPMA Journal, 2018 - Springer
Cancer with heavily economic and social burden is the hot point in the field of medical
research. Some remarkable achievements have been made; however, the exact …

Applications of metabolomics to study cancer metabolism

AK Kaushik, RJ DeBerardinis - … et Biophysica Acta (BBA)-Reviews on …, 2018 - Elsevier
Reprogrammed metabolism supports tumor growth and provides a potential source of
therapeutic targets and disease biomarkers. Mass spectrometry-based metabolomics has …

[HTML][HTML] Biomarker discovery in human prostate cancer: an update in metabolomics studies

AR Lima, M de Lourdes Bastos, M Carvalho… - Translational …, 2016 - Elsevier
Prostate cancer (PCa) is the most frequently diagnosed cancer and the second leading
cause of cancer death among men in Western countries. Current screening techniques are …

[HTML][HTML] The importance of DNA methylation in prostate cancer development

CE Massie, IG Mills, AG Lynch - The Journal of steroid biochemistry and …, 2017 - Elsevier
After briefly reviewing the nature of DNA methylation, its general role in cancer and the tools
available to interrogate it, we consider the literature surrounding DNA methylation as …

Sensors for diagnosis of prostate cancer: Looking beyond the prostate specific antigen

C Dejous, UM Krishnan - Biosensors and Bioelectronics, 2021 - Elsevier
Prostate cancer represents one of the most common forms of cancer affecting men across
the globe. Due to late diagnosis of this disease, the mortality of this condition is very high …

[HTML][HTML] c-Myc antagonises the transcriptional activity of the androgen receptor in prostate cancer affecting key gene networks

SJ Barfeld, A Urbanucci, HM Itkonen, L Fazli… - …, 2017 - thelancet.com
Prostate cancer (PCa) is the most common non-cutaneous cancer in men. The androgen
receptor (AR), a ligand-activated transcription factor, constitutes the main drug target for …

[HTML][HTML] Reconstruction of tissue-specific metabolic networks using CORDA

A Schultz, AA Qutub - PLoS computational biology, 2016 - journals.plos.org
Human metabolism involves thousands of reactions and metabolites. To interpret this
complexity, computational modeling becomes an essential experimental tool. One of the …

Metabolomic signatures of aggressive prostate cancer

JE McDunn, Z Li, KP Adam, BP Neri, RL Wolfert… - The …, 2013 - Wiley Online Library
BACKGROUND Current diagnostic techniques have increased the detection of prostate
cancer; however, these tools inadequately stratify patients to minimize mortality. Recent …