A pathophysiological framework of hippocampal dysfunction in ageing and disease

SA Small, SA Schobel, RB Buxton, MP Witter… - Nature Reviews …, 2011 - nature.com
The hippocampal formation has been implicated in a growing number of disorders, from
Alzheimer's disease and cognitive ageing to schizophrenia and depression. How can the …

How and when the fMRI BOLD signal relates to underlying neural activity: the danger in dissociation

A Ekstrom - Brain research reviews, 2010 - Elsevier
Functional magnetic resonance imaging (fMRI) has become the dominant means of
measuring behavior-related neural activity in the human brain. Yet the relation between the …

Interpreting oxygenation-based neuroimaging signals: the importance and the challenge of understanding brain oxygen metabolism

R Buxton - Frontiers in neuroenergetics, 2010 - frontiersin.org
Functional magnetic resonance imaging (fMRI) is widely used to map patterns of brain
activation based on blood oxygenation level dependent (BOLD) signal changes associated …

A review of calibrated blood oxygenation level‐dependent (BOLD) methods for the measurement of task‐induced changes in brain oxygen metabolism

NP Blockley, VEM Griffeth, AB Simon… - NMR in …, 2013 - Wiley Online Library
The dynamics of the blood oxygenation level‐dependent (BOLD) response are dependent
on changes in cerebral blood flow, cerebral blood volume and the cerebral metabolic rate of …

The oxygen paradox of neurovascular coupling

C Leithner, G Royl - Journal of Cerebral Blood Flow & …, 2014 - journals.sagepub.com
The coupling of cerebral blood flow (CBF) to neuronal activity is well preserved during
evolution. Upon changes in the neuronal activity, an incompletely understood coupling …

Resting‐State fMRI: Emerging Concepts for Future Clinical Application

S Amemiya, H Takao, O Abe - Journal of Magnetic Resonance …, 2024 - Wiley Online Library
Resting‐state functional magnetic resonance imaging (rsfMRI) has been developed as a
method of investigating spontaneous neural activity. Based on its low‐frequency signal …

Reproducibility of BOLD, perfusion, and CMRO2 measurements with calibrated-BOLD fMRI

O Leontiev, RB Buxton - Neuroimage, 2007 - Elsevier
The coupling of changes in cerebral blood flow (CBF) and cerebral metabolic rate of oxygen
(CMRO2) during brain activation can be characterized by an empirical index, n, defined as …

Regional differences in the coupling of cerebral blood flow and oxygen metabolism changes in response to activation: implications for BOLD-fMRI

BM Ances, O Leontiev, JE Perthen, C Liang… - Neuroimage, 2008 - Elsevier
Functional magnetic resonance imaging (fMRI) based on blood oxygenation level
dependent (BOLD) signal changes is a sensitive tool for mapping brain activation, but …

Caffeine-induced uncoupling of cerebral blood flow and oxygen metabolism: a calibrated BOLD fMRI study

JE Perthen, AE Lansing, J Liau, TT Liu, RB Buxton - Neuroimage, 2008 - Elsevier
Although functional MRI (fMRI) based on blood oxygenation level-dependent (BOLD) signal
changes is a sensitive tool for mapping brain activation, quantitative studies of the …

Cerebral oxygenation during locomotion is modulated by respiration

Q Zhang, M Roche, KW Gheres, E Chaigneau… - Nature …, 2019 - nature.com
In the brain, increased neural activity is correlated with increases of cerebral blood flow and
tissue oxygenation. However, how cerebral oxygen dynamics are controlled in the behaving …